In an epidemiological and biological stand point, lung cancer in never smokers is now recognized as a distinct disease entity. In this review, we provide a comprehensive view of the factors that contribute to l
IN a review of the evidence relating to familial aggregations of malignant disease in man it was concluded1 that these can generally be attributed to genetic factors. A similar conclusion2 has since been drawn with respect to lung cancer in man. The commonest form of predisposing inheritance app...
Few large scale genome wide association studies conducted recently have provided evidence that common variation on chromosome 15q25.1, 5p15.33 and 6p21.33 influences lung cancer risk and cancer types with strong environmental risk factors. It is hoped that newer research strategies, selecting candidate ...
Role of genetic factors in bronchial cancer. Based upon a case of anaplastic lung carcinoma in identical twinsHaving observed homozygotic identical twin brothers suffering simultaneously from anaplastic bronchial cancer leading rapidly to death in both cases, the authors assessed the frequency of such ...
the most common risk factor for lung cancer, only about one-tenth of the smokers develop lung cancer in their lifetimes3, which suggests that other factors play important roles in lung carcinogenesis4. Over the past few years, genome-wide association studies (GWASs) of lung cancer have ...
Genetic Factors Associated With Severe Cutaneous Adverse Reactions—Reply Wen-Hung Chung, MD, PhD1; Shuen-Iu Hung, PhD2 Author Affiliations JAMA. 2014;312(20):2166. doi:10.1001/jama.2014.14148 related articles icon Related Articles Original Investigation Phenytoin-Related Severe Cutaneous Adverse ...
Finally, tumor extrinsic factors such as clonal hematopoiesis, tumor-associated microbiome or the tissue architecture may also play an important role in tumor immune evasion. We expect that the combination of cancer genomics with high-resolution characterization of the tumor microenvironment will aid in...
Jinqiu Yuan1,2,3* and Yihang Pan1,3* Abstract Background Genetic and lifestyle factors both contribute to the pathogenesis of bladder cancer, but the extent to which the increased genetic risk can be mitigated by adhering to a healthy lifestyle ...
smoking, green tea consumption, genetic polymorphisms in the insulin-like growth factors and lung cancer risk吸烟,饮用绿茶,胰岛素样生长因子的基因多态性与肺癌风险 Smoking, Green Tea Consumption, Genetic Polymorphisms in the Insulin-Like Growth Factors and Lung Cancer Risk 1 2,3 4 5 5 5 I-Hsin ...
The impact of genetic variation on overall disease burden has not been comprehensively evaluated. We introduce an approach to estimate the effect of genetic risk factors on disability-adjusted life years (DALYs; ‘lost healthy life years’). We use genet