Pigs are very similar to humans in terms of anatomy, genetics, and physiology: (1) In terms of anatomy, the similarities in the size and morphology of their internal organs to those of humans allows various surgical and non-surgical procedures in clinical settings such as catheterization, heart...
In humans, for example, the gene SGLT1 is expressed in the heart. But in non-human primates, rats and mice, it is expressed only in the kidneys. Dual inhibitors of SGLT1 and SGLT2 have been shown to reduce heart failure, even though its exact role in the heart remains a mystery, sa...
Possibly before humans decided to settle down into an agricultural lifestyle, thepig made its home withus. Today, the domesticated version of the wild European boar has hundreds of varieties. Because of this variety, some scientists even considered the domesticated pig to be its own species (Sus...
Surprisingly a gag phylogenetic tree based on nucleotide sequences showed that the African relatives closest to all three household-derived SIVs were HIV-2 subtypes D and E from humans in the same West African areas. In one case, the SIV/HIV-2 cluster was from the same village. The ...
To assess biological specificity, we identified the top 1% highest-scoring SNPs from each model (platelet model, red cell model, GWAVA, CADD) after excluding all red cell or platelet trait-associated GWAS loci. We then used closestBed (https://bedtools.readthedocs.io/en/latest/content/tools/...
the study found that human activity is driving scores of mammals to shift their activity from the daytime into the dark hours of the night.As many animals have already been forced out of their local habitats,others are attempting to avoid interaction with humans by separating themselves in time...
The genetic variability of toxicant responses among indisviduals in humans and mammalian models requires practically untenable sample sizes to create comprehensive chemical hazard risk evaluations. To address this need, tractable model systems enable reproducible and efficient experimental workflows to collect...
baseline and 35d post insult. Midpoint is when the paw is closest to the pellet. Moreover, we sampled postures from different areas of this embedding to show differences/similarities between 35d after stroke and baseline for the different cohorts. The right bar panel summarizes how much behavior...
are under evolutionary constraint in humans24, and are over-represented in mutations that cause diseases in humans24,25. Phosphoproteomic data has also been combined with genomic and protein-binding specificity data to develop models that predict mutations likely to alter phosphorylation signaling in can...
G. Recovery of function in humans: cortical stimulation and pharmacological treatments after stroke. Neurobiol. Dis. 37, 243–251 (2010). Article CAS PubMed Google Scholar Taub, E., Uswatte, G. & Elbert, T. New treatments in neurorehabilitation founded on basic research. Nat. Rev. ...