Overgrowth syndromes are a heterogeneous group of rare disorders that are characterized by a global or localized tissue hypertrophy; the genetic causes of these syndromes are emerging as more patients’ genomes are molecularly scrutinized. The first report ofDNMT3Aovergrowth syndrome (DOS, also called ...
chicken faecal, human faecal, and soil samples. The relative abundances of taxa at the phylum level across the samples are compared.BNMDS analysis of the bacterial communities in broiler chicken carcasses (blue), broiler chicken faeces (pink), human faeces (purple), and soil (orange), based o...
The key to the relative success of animals such as chimpanzees and baboons is living within a truly circular economy. Sunlight falling on trees provides the food they need. Waste products of their economy come back to the forest ecosystem as fertilizer. Pre-humans lost the circular economy ...
The directed chamfer distance DD(T R) between a test point set T and a reference point set R is obtained by summing the distance contributions of the individual points t of set T, dd(t R) the latter is de ned as the distance from t to the nearest point in set R DD(T R) X dd...
Waist circumference measurements to the nearest 0.1 cm were taken at the mid-point between the bottom rib and the hip bone, without restrictive garments using a flexible non expandable tape measure. Dietary Intake Three days before the collection of baseline measurements and three times during the ...
We next explored the genetic relationship of sSV carrying haplotypes to test whether sSVs have formed in a multi-step process rather than through 'one-time' complex rearrangements. We hypothesized that, should the sSV hypothesis be true, haplotypes of higher sSV depth should be genetically more ...
During embryogenesis, the liver is the site of hepatogenesis and hematopoiesis and contains many cell lineages derived from the endoderm and mesoderm. However, the characteristics and developmental programs of many of these cell lineages remain unclear,
(inferred here by distance to nearest rivers) also appeared to be an important additional characteristic (Table1) since many likely expansion routes generally followed major rivers such as the Lena River toward Beringia, both the Dnieper and Danube in Western Europe, the Yellow River in south-...
(one or both, depending on the POE model, see Fig.1) and their offspring is reduced relative to that between full siblings45. Therefore, for CpGs sites for which methylation levels are influenced by POEs caused by imprinting, matrixSwhen fitted simultaneously with the additive genetic components...
We next sought to explore the transcriptomic landscape of CD genetic susceptibility loci within the MAT at single-cell level. We found an overall higher enrichment of genome-wide association study (GWAS) genes11from CD-associated loci in MSCs, ECs, macrophages, monocytes and neutrophils (Supplementa...