Scanu A. Lipoprotein(a): a genetic risk factor for premature coronary heart disease. JAMA 1992; 267: 3326-9.Scanu AM. Lipoprotein(a): a genetic risk factor for premature coronary heart disease. JAMA 1992; 267: 3326–9Scanu AM. Lipoprotein(a) ,a genetic risk factor for premature ...
"Among those at high genetic risk, statins confer a greater benefit for primary prevention of coronary heart disease," said Sekar Kathiresan, MD, from Massachusetts General Hospital in Boston and the Broad Institute in Cambridge. Dr Kathiresan and his colleagues demonstrated this in a recent stu...
through low concentrations of a biomarker in the body called adiponectin. It may also demonstrate why certain lifestyle factors such as consumption of oily fish and regular exercise are so important for warding off the risk of heartdisease. ...
In addition to the early predictive power of the genomic risk score alone, they found that integrating this information with known risk factors improved their ability to predict the risk of developing heart disease 10 years into the future, especially for people over 60 years of age. "Traditional...
The impact of genetic variation on overall disease burden has not been comprehensively evaluated. We introduce an approach to estimate the effect of genetic risk factors on disability-adjusted life years (DALYs; ‘lost healthy life years’). We use genet
coronary heart disease, we combined multiple variants that had been associated with coronary heart disease in several studies into a genetic risk score and asked whether a high genetic risk score would be significantly associated with coronary heart disease after accounting for traditional risk factors....
One such study a few years ago found that healthy living could help overcome genetic risk for heart disease. Now researchers have shown the same to be true for dementia. Dr. Elzbieta Kuzma and colleagues at the University of Exeter Medical School in England used the UK Biobank to study nearl...
Objective-Circulating levels of total cholesterol, low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol, and triglycerides are recognized risk factors for cardiovascular disease. We tested the hypothesis that the cumulative effects of common genetic variants for lipids ...
Polygenic risk scores, which estimate a person's disease risk based on thousands or millions of common genetic variants, perform poorly in screening and prediction of common diseases such as heart disease, according to a new study led by UCL (University
SUDEP is suspected to be multifactorial and may relate to autonomic dysfunc- tion, abnormalities in heart rate variability or catecholamine surge, antiepileptic medications and underlying cardiac arrhythmias.40,41 Risk factors for SUDEP in patients treated with antiepileptic medication include poor patient ...