Prostate Cancer and Prostatic DiseasesEeles RA (1999) Genetic predisposition to prostate cancer. Prostate Cancer Prostatic Dis 2: 9-15.Eeles RA: Genetic predisposition to prostate cancer. Prostate Cancer Prostatic Dis 1999, 2: 9–15.Eeles RA. Genetic predisposition to prostate cancer. Prostate ...
Genetic predisposition to prostate cancer.Prostate cancer has been known to run in families for about 40 years and epidemiological studies have demonstrated an increased risk to close relatives of cases. This risk rises markedly when the closeness and number of cases in a cluster increases. There ...
to prostate cancer. We further evaluated the mechanism underlying the top hit,PCAT1, and found that a risk-associated variant at rs7463708 increases binding of ONECUT2, a novel androgen receptor (AR)-interacting transcription factor, at a distal enhancer that loops to thePCAT1promoter, resulting...
Genetic predisposition to prostate cancer: Possible explanations for ethnic differences in risk BACKGROUND It seems unlikely that the large ethnic differences in prostate cancer risk can be explained completely by ethnic differences in diet or other l... A Shibata,AS Whittemore - 《Prostate》 被引量...
Early onset and familial predisposition to prostate cancer significantly enhance the probability for breast cancer in first degree relatives Genetic predisposition accounts for 鈮 10% of all cancer of the prostate (CaP) and is therefore considered a major risk factor, together with age and ethnic.....
Molecular TherapyLILACH AGEMY; ITAI KELA; RAFI PFEFFER; EYTAN DOMANY; AVI ORR-URTREGER; BAR SHIRA ANAT; ZELIG ESHHAR: ' GENETIC PREDISPOSITION OF THE SENSITIVITY OF PROSTATE CANCER TO RADIATHERAPY ', June 2006, AMERICAN-SOCIETY OF GENE THERAPY...
The IMPACT study (Identification of Men with a genetic predisposition to ProstAte Cancer: Targeted screening in men at higher genetic risk and controls; www.impact-study.co.uk) is an international multi-centre study evaluating the role of targeted PSA screening in men with a BRCA1 or BRCA2 ...
to capture RNA transcripts produced from intronic and intergenic regions within 1.5-Mb intervals surrounding known breast cancer GWAS signals at the time of capture design (139/196 signals; Fig.1a; Additional file2: Table S3). Additional control sequences were added to the capture design to ...
There is strong evidence of a genetic predisposition to prostate cancer. Recent advances in genetic sequencing technologies have permitted significant advances in the field. This article reviews the genetic basis underlying prostate cancer, and highlights the epidemiology and potential clinical usefulness of...
The regulatory regions discovered by eQTL mapping increase our understanding of the relationship between regulation of gene expression and susceptibility to PrCa and provide a valuable starting point for future functional research. 展开 关键词: prostate cancer risk genetic predisposition susceptibility loci ...