Identification of new genetic risk factors for prostate cancer. Asian Journal of Andrology . 2009; 11 (1):49–55.Guy M, Kote-Jarai Z, Giles GG, Al Olama AA, Jugurnauth SK, Mulholland S, Leongamornlert DA, Edwards SM, Morrison J, Field HI, Southey MC, Severi G, Donovan JL, ...
Genetic susceptibility has a stronger risk value of the prediction that modifiable risk factors. While the added value of each SNP is small, the combination of 56 SNPs adds to the predictive ability of the risk model.Similar content being viewed by others Prostate cancer risk prediction using a...
Genetic epidemiology of prostate cancer in the Utah Mormon genealogy. Cancer Surv. 1982;1:47–69. Cannon-Albright L, Eeles RA. Progress in prostate cancer. Nat Genet. 1995;9(4):336–8. Steele R, Lees RE, Kraus AS, Rao C. Sexual factors in the epidemiology of cancer of the prostate...
If you or someone you love has prostate cancer, there's no way to find its exact cause. Like any cancer type, prostate cancer arises when changes in your cells at the genetic level make them grow and divide more than normal. Sometimes, those cells may grow or spread to other nearby par...
Men with a family history of prostate cancer and African-American men are particularly susceptible to the disease, with a twofold to sevenfold increased risk. Assessing risk in these populations has been difficult.
“This is one of the first genetic variants ever found to confer significant risk of a major cancer among the population in general. Most previously identified cancer genes have their effect on cancer risk only in families with a clear family history of cancer, or are only found mutated in ...
Recent years have heralded a marked expansion in our understanding of the somatic genetic basis of prostate cancer. Of considerable importance has been the discovery of recurrent gene fusions that render ETS transcription factors under the control of androgen-responsive or other promoters2,3,4,5. Th...
Tina Bianco-Miotto, in Cancer Letters, 2014 1 Introduction Prostate cancer is one of the most commonly diagnosed cancers in men of developed Western countries. Globally, it is the 2nd most commonly diagnosed and 6th leading cause of cancer death in men [1]. Several risk factors such as ...
Translating genetic risk factors for prostate cancer to the clinic: 2013 and beyond. Future Oncol. 10, 1679–1694 (2014). Article PubMed CAS Google Scholar Conti, D. V. & Gauderman, W. J. SNPs, haplotypes, and model selection in a candidate gene region: the SIMPle analysis for ...
patients were recommended for testing to identify mutations associated with prostate cancer based on family history of prostate cancer, hereditary breast orovarian cancer, and Ashkenazi Jewish ancestry, among other factors. Testing was performed at routine clinic visits, with follow-up genetic counseling...