From common to rare variants: the genetic component of Alzheimer disease. Hum. Hered. 81, 129-141.Nicolas G, Charbonnier C, Campion D. From Common to Rare Var- iants: The Genetic Component of Alzheimer Disease. Hum Hered 2016;81:129-41....
We have previously identified a network of higher-order brain regions particularly vulnerable to the ageing process, schizophrenia and Alzheimer’s disease. However, it remains unknown what the genetic influences on this fragile brain network are, and whether it can be altered by the most common mo...
The advent of artificial intelligence (AI) has provided approaches to investigate various aspects of human brain health1,2, such as normal brain aging3, neurodegenerative disorders such as Alzheimer’s disease (AD)4, and brain cancer5. Based on magnetic resonance imaging (MRI), AI-derived measur...
We normalized these 1339 cells and conducted a principal component analysis (PCA) to filter out the outliers assuming that samples in the first two principal components follow a multivariate normal distribution, leaving 1282 cells within 95% confidence interval (Supplementary Figure S1). We ...
Reports on the discovery of a genetic component for some types of Alzheimer's disease. Three identified genetic loci in which missense mutations lead to an earlier-onset form of Alzheimer's disease.DaleDavidC.FedermanDanielD.EBSCO_AspCortlandt Forum...
Difficulties with conclusively diagnosing Alzheimer's patients and the apparent multifactorial, genetic/environmental interactions of the disease, continue to complicate attempts to study and understand the disease. Although families with an apparent autosomal dominant trait are potentially quite valuable in ...
(Alzheimer’s disease (AD) and schizophrenia (SCZ)), and one behavioral trait (educational attainment years (EAY)). For the traits for which the associated SNPs are significantly more differentiated among the global populations than expected under drift, we then measure the direction of genetic ...
Inflammation and oxidative stress after hypoxic-ischemic brain injury may be modified by genetic variability in addition to therapeutic hypothermia. The aim of our study was to evaluate the association between the polymorphisms in genes of antioxidant an
Systematic meta-analyses of Alzheimer disease genetic association studies: The AlzGene database. Nat. Genet. 2007, 39, 17–23. [Google Scholar] [CrossRef] Fullerton, S.M.; Clark, A.G.; Weiss, K.M.; Nickerson, D.A.; Taylor, S.L.; Stengård, J.H.; Salomaa, V.; Vartiainen, ...
Demyelinating disorders show impaired remyelination due to failure in the differentiation of oligodendrocyte progenitor cells (OPCs) into mature myelin-forming oligodendrocytes, a process driven by microglia–OPC crosstalk. Through conducting a transcrip