Difficulties with conclusively diagnosing Alzheimer's patients and the apparent multifactorial, genetic/environmental interactions of the disease, continue to complicate attempts to study and understand the disease. Although families with an apparent autosomal dominant trait are potentially quite valuable in ...
The advent of artificial intelligence (AI) has provided approaches to investigate various aspects of human brain health1,2, such as normal brain aging3, neurodegenerative disorders such as Alzheimer’s disease (AD)4, and brain cancer5. Based on magnetic resonance imaging (MRI), AI-derived measur...
Direction of genetic differentiation for height, WHRadjBMI and SCZ in the 1000G populations. The colored dot represents the estimated deviation (in s.d. units) of the mean PRS based on the trait-associated SNPs clumped atP<5×10−6of a population from the overall mean across populations. ...
The first component of the PLS (PLS1) was the linear combination of the contributions of all genes to the gene co-expression networks that exhibited the strongest correlation with cerebellar connectivity alterations. The weight of each gene to form the PLS1 was converted to a Z score by ...
Parkinson’s disease mitophagy PINK1 Parkin Abbreviations AD Alzheimer’s disease ALS Amyotrophic lateral sclerosis AMPK AMP-activated protein kinase ATG Autophagy-related genes BAG-1 BAG family molecular chaperone regulator 1 CHIP Carboxy-terminus of Hsc70-interacting protein CMA Chaperone-mediated autophagy...
We normalized these 1339 cells and conducted a principal component analysis (PCA) to filter out the outliers assuming that samples in the first two principal components follow a multivariate normal distribution, leaving 1282 cells within 95% confidence interval (Supplementary Figure S1). We ...
From common to rare variants: the genetic component of Alzheimer disease. Hum. Hered. 81, 129-141.Nicolas G, Charbonnier C, Campion D. From Common to Rare Var- iants: The Genetic Component of Alzheimer Disease. Hum Hered 2016;81:129-41....
Reports on the discovery of a genetic component for some types of Alzheimer's disease. Three identified genetic loci in which missense mutations lead to an earlier-onset form of Alzheimer's disease.DaleDavidC.FedermanDanielD.Cortlandt Forum
Research topic(s) CP: Cancer CP: Metabolism Keywords neuroendocrine tumor pheochromocytoma SDHB Cdk5 AMPK PRKAG2 p53 Warburg effect cancer bioenergetics senescence Introduction The tricarboxylic acid (TCA) cycle is the critical energy-yielding component of cellular respiration and the centerpiece of cell...
Enrichment of gene ontology terms on the genes from TNFAIP3-subnetwork was done as described above (analysis performed in June 2021) for GO:BP, cellular component (GO:CC) and molecular function (GO:MF). 2.3. Study population and dataset The patient cohort consisted of 228 index patients with...