Other mutations in the TREM2 gene have been associated with Alzheimer's disease, and it was previously shown that persons who carry two copies of this particular mutation have a very rare disorder called Nasu-Hakola disease. The disease is characterized by onset of dementia in midlife and polycy...
AlzheimerischemiacerebralNeurodegeneration in the brain after ischemia with reperfusion mimicking the neuropathology of Alzheimer's disease: Brain ischemia with reperfusion, which is one of the main causes of morbidity and mortality in the world, triggers various neuropathological changes characteristic for...
In order to understand the pathogenic factors that initiate the processes of Alzheimer's disease (AD), a method of inference of multiple differential modul... Z Wang,X Yan,C Zhao - 《Experimental & Therapeutic Medicine》 被引量: 0发表: 2017年 Alzheimer's disease is associated with reduced ...
600 participants with AD and nearly 4,600 cognitively healthy elderly controls. DNA sequence data were generated by the Alzheimer Disease Sequencing Project, a large NIH-funded initiative that emerged from the National Alzheimer's Act of 2012
, Liang, Winnie S. 展开 摘要: Alzheimer's disease (AD) is characterized by deficits in cerebral metabolic rates of glucose in the posterior cingulate (PC) and precuneus in AD subjects, and in APOEε4 carriers, decades before the onset of measureable cognitive deficits. However, the cellular ...
Thus, these polymorphisms are unlikely to be associated with AD risk. 2001 Wiley-Liss, Inc. 展开 关键词: Alzheimer disease dementia renin angiotensinogen MRC CFAS study DOI: 10.1002/ajmg.10044 被引量: 15 年份: 2010 收藏 引用 批量引用 报错 分享 ...
Selective vulnerability of different brain regions is seen in many neurodegenerative disorders. The hippocampus and cortex are selectively vulnerable in Alzheimer’s disease (AD), however the degree of involvement of the different brain regions differs a
Human middle temporal gyrus (MTG) is a vulnerable brain region in early Alzheimer’s disease (AD), but little is known about the molecular mechanisms underlying this regional vulnerability. Here we utilize the 10 × Visium platform to define the sp
Many genes linked to late-onset Alzheimer's disease (AD) are expressed in myeloid cells and regulated by a single protein, according to research conducted at the Icahn School of Medicine at Mount Sinai and published June 19 in the journal Nature Neurosci
is a strong association between Alzheimer's disease and the APOE4 allele, which has reduced efficacy in cholesterol delivery to cells, and in stimulating neurite outgrowth [98]. Downregulation in the expression of genes involved in the cholesterol synthesis pathway is seen in cortical tissue of ...