The sampling theory of selectively neutral alleles. Theor Popul Biol 3: 87–112. Goudet J, Bu¨ chi L (2006). The effects of dominance, regular inbreeding and sampling design on Qst, an estimator of population differentiation for quantitative traits. Genetics 172: 1337–1347. Goudet J, ...
Each mammalian autosomal gene is represented by two alleles in diploid cells. To our knowledge, no insights have been made in regard to allele-specific regulatory mechanisms of autosomes. Here we use allele-specific single cell transcriptomic analysis to
Moreover, dosage pyramiding effects of the highly favorable SNP alleles and significant linear correlations between the numbers of highly favorable alleles and the phenotypic values of the target traits were identified. Most importantly, a major locus (rs13562854) on chromosome Dt3 and a potential ...
Type 2 diabetes risk alleles reduce KLF14 expression in adipose tissue, which leads to gene expression changes and cellular effects consistent with diabetes phenotypes [90]. Other examples include variants associated with fetal hemoglobin levels, through effects on enhancers of MYB and BCL11A [91,92...
Unraveling the polygenic architecture of complex traits using blood eQTL meta-analysis. Posted online October 19, 2018. bioRxiv. doi:10.1101/447367Google Scholar 13. Pardiñas AF, Holmans P, Pocklington AJ, et al; GERAD1 Consortium; CRESTAR Consortium. Common schizophrenia alleles ...
This review examines the roles that alleles of circadian clock genes have played in domestication and improvement of crop plants. The focus here is on three groups of circadian clock genes essential to clock function in Arabidopsis thaliana: PSEUDO-RESPONSE REGULATORs, GIGANTEA, and the evening ...
For neuropsychiatric disorders that usually manifest later in life, such as schizophrenia, bipolar disorder, and major depression, genome-wide association studies (GWAS) have in fact elucidated a polygenic scenario with multiple alleles of very small effect [16–19]. Although most of the GWAS ...
Such an approach is being used for the Pm3 gene (a CNL) for resistance to powdery mildew in wheat, for which 17 resistance-promoting alleles have been identified [120,121]. A huge number of loci for resistance to pathogens have been mapped in many species, and a number of these are ...
We found strong support for the dopamine gene by climatic stress interaction: Population genetic differences in dopamine predicted personality traits at the population level in demanding climates, but not in temperate, less demanding climates, even when controlling for known correlates of personality ...
models were used to assess the association of the genotypes (common homozygote genotype = 1, heterozygote genotype = 2, rare homozygote genotype = 3), alleles (the minor allele non-carrier = 1, the minor allele car- rier = 2), haplotypes (the ...