Treatment is typically focused on disease management rather than developmental and behavioral comorbidities that may affect quality of life or contribute to poor disease control. The purpose of this study was to explore the prevalence of developmental and behavioral comorbidities of asthma and the role ...
The objective of this study was to identify reliable germline mutations that highly affect lung cancer risk and to discover novel genes that are involved in the etiology and development of lung cancer. We analyzed two independent datasets comprising 39,146 individuals of European ancestry that have ...
Lung cancer is emerging as a paradigm for disease molecular subtyping, facilitating targeted therapy based on driving somatic alterations. Here we perform transcriptome analysis of 153 samples representing lung adenocarcinomas, squamous cell carcinomas,
Therefore, it is not surprising that mutations in genes that affect autophagic capacity can lead to severe illnesses. It must be noted that the autophagy defects are indirect in some of these pathologies, such as in lysosomal storage disorders including Fabry and Pompe diseases where lysosome ...
We identified selective biological signals associated with different subtypes of lung cancer. On further examining the differential expression of genes in detail, we found that 3 genes (GUSBP8, CHL1, CXCL1) were common between upregulated DEGs in NSCLC and downregulated DEGs in SCLC and 8 genes...
were significantly increased in breast cancer cells. However, the expression of three ARGs, SLC39A6, EDA2R and LAMB, was significantly reduced in breast cancer cells (Fig.8). These results suggest that these genes may be closely related to the prognosis of breast cancer and may be used as...
There are other structural domains that also affect the function of TRP channels, such as the coiled-coil domain, nudix hydrolase domain, and EF hand, but the types of structural domains vary between different TRP channels [6]. TRP channels can be gated by temperature and have extensive ...
The present work has some limitations as causal inference using MR is subject to horizontal pleiotropy (i.e. gene variants that affect the outcome through an alternative pathway) [67]. However, the assessment of pleiotropy with the Cochran’s Q test and also the implementation of sensitivity ana...
These findings potentially suggest that miRNAs targeting the activity of NF-κB, such as miR-181, miR-34a and others mentioned in previous sections, might affect SIRT1 levels without directly targeting its mRNA. If such effects were observed in further studies, then some of the anti-inflammatory...
Grainyhead-like 1 (GRHL1) is a transcription factor involved in embryonic development. However, little is known about the biological functions of GRHL1 in cancer. In this study, we found that GRHL1 was upregulated in non-small cell lung cancer (NSCLC) an