Some individuals show a discrepancy between cognition and the amount of neuropathological changes characteristic for Alzheimer’s disease (AD). This phenomenon has been referred to as ‘resilience’. The molecular and cellular underpinnings of resilience remain poorly understood. To obtain an unbiased ...
A core transcriptional signature of human microglia: derivation and utility in describing region-dependent alterations associated with Alzheimer’s disease. Glia. 2019;67:1240–53. Article PubMed Google Scholar Patel T, Carnwath TP, Wang X, Allen M, Lincoln SJ, Lewis-Tuffin LJ, et al. ...
There is a strong association between Alzheimer's disease and the APOE4 allele, which has reduced efficacy in cholesterol delivery to cells, and in stimulating neurite outgrowth [98]. Downregulation in the expression of genes involved in the cholesterol synthesis pathway is seen in cortical tissue ...
genome-based personalized medical care (Figure 1).1 In the Disease Genes division, the five most frequent diseases in developed countries that have a harmful impact on lifelong health and quality-of-life were selected, namely essential hypertension, diabetes, cancer, asthma and Alzheimer's disease...
Genome-wide association studies (GWAS) have implicated this gene cluster region with multiple phenotypes: lipid traits, including low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, and triglyceride levels [1], [2], [3], [4]; late-onset Alzheimer's disease (LOAD), ...
influenced by XBP1 and ATF6 and quantified the expression of a subset of genes in the human post-mortem spinal cord from amyotrophic lateral sclerosis (ALS) cases and in the frontal and temporal cortex from frontotemporal lobar degeneration (FTLD) and Alzheimer’s disease (AD) cases and ...
Guy, S. Millecamps, D. Deffond, L. Lacomblez, V. Golfier, D. Hannequin, F. Salachas, W. Camu, M. Didic, B. Dubois, V. Meininger, I. Ber, Brice, A. Le FUS mutations in frontotemporal lobar degeneration with amyotrophic lateral sclerosis J. Alzheimer's Dis., 22 (2010), pp...
(99%) have less than 200 publications and have a wide range of scores, reflecting the fact that they are reported in one or several sources with different levels of curation. Moreover, the analysis of this plot let us identify some interesting outliers. First, the associationsAPP-Alzheimer ...
RNA sequencing (RNA-Seq) and mass-spectrometry-based proteomics data are often integrated in proteogenomic studies to assist in the prediction of eukaryote genome features, such as genes, splicing, single-nucleotide (SNVs), and single-amino-acid variants