We observe this to occur significantly more in cancer than in normal and show that the majority of TEs increase the expression of affected nearby genes. Interestingly, we discover that TEs affecting known cancer driver genes in cancer have for most part no significant effect on these genes in ...
Each mammalian autosomal gene is represented by two alleles in diploid cells. To our knowledge, no insights have been made in regard to allele-specific regulatory mechanisms of autosomes. Here we use allele-specific single cell transcriptomic analysis to elucidate the establishment of monoallelic gene...
s laws states that genes are transferred as separate and distinct units from one generation to the next. The two members (alleles) of agenepair, one on each of paired chromosomes, separate during the formation of sex cells by a parent organism. One-half of the sex cells will have one ...
A clone showing monoallelic gene expression must show greater than 2.33 fold difference between the expression levels of the two alleles. StMA gene expression was defined by examining genetically identical sister clonal lines where additional clones showed either biallelic (equal ...
The first case is a variant with its reference and alternate alleles ‘flipped’ with respect to the LD reference. The GWAS z scores or eQTL weights in the prediction model of the flipped variants should have their signs reversed to be consistent with the LD reference. The second case is a...
1). Additionally, indigenous duck breeds clustered more closely with each other, indicating that they have a closer genetic relationship and probably share a similar domestication history. Although the precise origins of Pekin ducks are unclear11, our phylogenetic tree (Fig. 1c) suggested that both...
Furthermore, the Fas/FasL system may have a considerable role in cancer beginning and prognosis. Therefore, SNPs which acquire the potential to change the expression of these genes have been anticipated to be crucial in the genetic propensity to cancer [4]. 2. Objective This work is an ...
Therefore, the study of grain size has become a hot research topic among rice geneticists and breeders. At present, more than 400 quantitative trait loci (QTLs) linked to grain size have been mapped on all 12 chromosomes of rice, and over 80 grain size-related genes have been cloned (Huang...
Furthermore, ASD cases were more likely to have two damaging missense variants in candidate genes than controls. Finally, gene-based rare variant association implicates genes functioning in excitatory neurotransmission and neurite outgrowth and guidance pathways including CACNAD2, KCNH7, and NRXN1. ...
In wheat, during last two decades, more than 50 genes have been suggested for MAS, for diseases including powdery mildew, leaf rust, stem rust, stripe rust, cereal cyst nematode, hessian fly, wheat streak mosaic virus etc (Gupta et al., 2010; Dreisigacker et al., 2016). As a result,...