We use somatic and germline data on lung adenocarcinomas from The Cancer Genome Atlas in conjunction with a meta゛nalyzed lung cancer GWAS to identify novel genes associated with lung cancer.doi:10.1002/gepi.22275Jack PatteeXiaowei ZhanGuanghua Xiao...
Pvalues were determined by logistic regression analysis adjusted by age, gender, smoking status and the principal components.aStratified analyses of the association between rs56009889 and Lung cancer. Compared to non-carriers, L2307F carriers had an increased risk of lung cancer with ORs being 4.19...
A new study led by researchers at The University of Texas MD Anderson Cancer Center has discovered that co-occurring mutations in three tumor suppressor genes—KEAP1, SMARCA4 and CDKN2A—are linked with poor clinical outcomes in patients with KRAS G12C-mutant non-small cell lung cancer (NSCLC)...
Reduced expression of class II histone deacetylase genes is associated with poor prognosis in lung cancer patients . Int J Cancer 2004; 112 : 26–32... H Osada,Y Tatematsu,H Saito,... - 《International Journal of Cancer》 被引量: 388发表: 2004年 Expression of sirtuin 1 and 2 is asso...
Susceptibility loci for lung cancer are associated with mRNA levels of nearby genes in the lung Recent studies identified three genetic loci reproducibly associated with lung cancer in populations of European ancestry, namely 15q25, 5p15 and 6p21. The goals of this study are first to confirm whe...
With 10% FDR control, the DE genes in S2 found by PD for lung cancer were significantly enriched in 14 pathways (Fig. 3a). However, none of these pathways was identified as significant by enrichment analysis with the same FDR control for the 10,945 DE genes found by SAM with 5% FDR ...
Functional enrichment analysis indicated that these feature genes upregulated were significantly associated with regulating cell death, apoptosis, and IL-17 signaling pathway (Fig. 2H). The downregulated feature genes are mainly enriched in the metabolic process (Fig. 2I). Figure 2 LASSO, RF, and...
Total 367 lung cancer associated genes sequences were down- loaded from GenBank and Ensembal. The nucleotide content distributes of each gene sequences was first calculated via Matlab. Each gene sequence was then defined as a point within a vector space of 84 dimensional, basing on the ...
Lung cancer is the most common cause of cancer death in Japanese males, the incidence having increased markedly in recent years. Carcinogen exposure such as to tobacco-smoke and air pollution are associated with the probability of developing lung cancer. Aquired somatic mutations play an important ...
CTHRC1 expresses in cancer-associated fibroblasts and is associated with resistance to anti-androgen therapy in prostate cancer Hai-qi Liang Qi-huan He Ji-wen Cheng Original Article26 February 2025 Integrative analysis of genetic variability and functional traits in lung adenocarcinoma epithelial cells ...