the human geneNCF4was found to be associated with arthritis as a translation of studies on a rat arthritis model. The gene encodes a component of the NADPH oxidase complex and these studies catalyzed the development of a new therapy for arthritis, based on the use ...
We found a highly significant association betweenTUBB1and platelet counts (P-value = 7.85e − 11; normalized beta = −6.50; functional annotation Filter 2) that was also Bonferroni significant via functional annotation filters 1 and 3.TUBB1was also associated with the related m...
These alleles are associated with reduced catalytic activity of the wild-type (CYP2C9*1). The CYP2C9*2 allele is more moderately defective while CYP2C9*14 was found to be highly defective in in vitro studies [11]. CYP2D6, "the only functional gene in the CYP2D human subfamily", is...