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diseases. The journal has worldwide authorship, and a broad scope in basic and translational biomedical research of molecular biology, molecular genetics, and cell biology, including but not limited to cell proliferation and apoptosis, signal transduction, stem cell biology, developmental biology, gene...
In this work, to circumvent this issue and elucidate the impact of diseases on the transcriptome program at a large scale and in a principled way, we propose a reverse transcriptome-wide Mendelian randomization approach (revTWMR), which integrates summary-level data from GWAS andtrans-eQTLs studi...
publishes rigorously peer-reviewed and high quality original articles and authoritative reviews that focus on the molecular bases of human diseases. Emphasis will be placed on hypothesis-driven, mechanistic studies relevant to pathogenesis and/or experimental therapeutics of human diseases. The journal has...
The main mechanism of anticoagulant treatment for ONFH is the alleviation of hypercoagulability104. Hypercoagulability has been demonstrated to not only induce primary ONFH3,104,105, but also ONFH that is secondary to certain diseases, such as thrombophilia106,107and antiphospholipid syndrome23,108....
Illum LRH, Bak ST, Lund S, Nielsen AL (2018) DNA methylation in epigenetic inheritance of metabolic diseases through the male germ line. J Mol Endocrinol 60:R39–R56 Article PubMed Google Scholar Immler S, Pryke SR, Birkhead TR, Griffith SC (2010) Pronounced within-individual plasticity ...
They play an important role in the development of cardiovascular diseases such as atherosclerosis, myocardial infarction, and diabetic coronary heart disease [37,38,39]. Studies on MMVD progression in dogs have shown that turbulent high-velocity blood flow and changes in blood shear stress around ...
the effect of activators surpasses those of the inhibitors, and this phenomenon can lead to certain aggressive diseases, including tumor progression and metastasis3. In other words, angiogenesis plays a prominent role in tumor growth and proliferation and is approved to be a prerequisite for metastati...
J. The roles of PINK1, parkin, and mitochondrial fidelity in Parkinson’s disease. Neuron 85, 257–273 (2015). Article CAS PubMed PubMed Central Google Scholar Li, J. et al. PINK1/parkin-mediated mitophagy in neurodegenerative diseases. Ageing Res. Rev. 84, 101817 (2023). Article CAS ...
Targeting OS is considered a novel treatment modality in various diseases, including cancer10. Current evidences support that the dysfunction of ROS is a risk factor and antioxidant supplementation is a preventive method for PC11,12. Lipids, including triglycerides, cholesterol, and phospholipids, are...