Osteonecrosis of the femoral head (ONFH) is a multifactorial disease leading to severely limited function. By far, the etiology and pathogenesis of ONFH are not fully understood, and surgery is the only effective way to treat ONFH. This study aims to identify hub genes and therapeutic drugs in...
Oxidative stress (OS), which impacts lipid metabolic reprogramming, can affect the biological activities of cancer cells. How oxidative stress and phospholipid metabolism (OSPM) influence the prognosis of pancreatic cancer (PC) needs to be elucidated. Th
The objective of this research was to use comparative genomics to investigate dioecy within theAmaranthusgenus. We obtained whole-genome sequence from seven dioecious amaranths, and report genome characteristics, transposable element (TE) proliferation patterns, and phylogenomic relationships among the specie...
Quinoa is a highly nutritious and novel crop that is resistant to various abiotic stresses. However, its growth and development is restricted due to its limited utilization of soil phosphorus. Studies on the levels of phosphorus in quinoa seedlings are l
The metagenomics data reported in this paper have been deposited in the Genome Sequence Archive in the National Genomics Data Center, China National Center for Bioinformation / Beijing Institute of Genomics, Chinese Academy of Sciences that are publicly accessible athttps://ngdc.cncb.ac.cn/gsa(GSA...
Wood is a secondary xylem generated by vascular cambium. Vascular cambium activities mainly include cambium proliferation and vascular tissue formation through secondary growth, thereby producing new secondary phloem inward and secondary xylem outward an
Furthermore, the rise in genomics research and development activities that demonstrate the efficiency of CRISPR technologies is likely to boost market growth over the forecast period. For instance, in May 2022, Vertex and CRISPR Therapeutics presented new clinical data on investigational CRISPR/Cas9 Ge...
Conclusions The extensive atlas of GWAS, eQTL, fine-mapping, and transcriptome-wide association studies aid in the suggestion of potentially functional variants and genes in cattle agronomic traits and will be an invaluable source for genomics and breeding in beef cattle.Introduction...
Comparing transcript levels between healthy and diseased individuals allows the identification of differentially expressed genes, which may be causes, consequences or mere correlates of the disease under scrutiny. We propose a method to decompose the obs
Through the largest global assembly of lung-function genomics studies to date we: (1) undertook a multi-ancestry GWAS meta-analysis of lung-function traits in 588,452 individuals to detect novel signals, improve fine mapping and estimate heterogeneity in allelic effects attributable to ancestry; (...