Coronary artery disease (CAD) is a complex trait disorder and a leading cause of morbidity-mortality. The dysregulated expression of genes and activation of pathways culminate in the development of vascular atheromatous plaque, a hallmark feature of CAD [1]. Functional assessment and cell tracking e...
Code availability The custom pipelines and scripts were deposited at Zenodo106 and GitHub (https://github.com/ZhaofangHan/Acorn-Barnacle-Genome)107. References Love, A. C. Darwin and Cirripedia prior to 1846: exploring the origins of the barnacle research. J. Hist. Biol. 35, 251–289 (200...
Genome-wide screenings of “essential genes”, i.e., genes required for an organism or cell survival, have been traditionally conducted in vitro in cancer cell lines, limiting the translation of results to other tissues and non-cancerous cells. Recently, an in vivo screening was conducted in...
Upon translocation, TALEs bind via a well-deciphered recognition code to specific sequences in the promoter region of targeted host genes, thereby activating expression of those targeted genes. Gene activation induced by artificially designed TALEs (dTALEs) has been studied in multiple organisms, but...
five knock-outed avr genes in PXO99A could code virulence factors to induce rice leaf lesion.It was concluded that avr genes avrXa14,avrXa21,avrxa13 could be contained in five series-wound avr genes and some pathogenic fitness factors in PXO99A could be associated with the interaction with ...
Whether this is caused by a general increase in nucleosome fluidity due to charge neutralization or by a more specific code is still matter of debate. By using a set of glucose-repressed Adr1-dependent genes of Saccharomyces cerevisiae , whose transcription was previously shown to require both ...
A technology developed recently in the laboratory of co-author Jay Shendure, PhD, from the University of Washington, allowed the research team to rapidly obtain a unique read-out—like a genetic bar code—each time one of the enhancers was involved in gene activation. ...
Data and code availability ReferencesShow full outline Figures (7) Show 1 more figure Tables (1) Table Extras (7) Download all Document S1. Figure S1 Table S1. Super-enhancers and super-enhancers associated genes and SE associated genes in SCLC, related to Figure 2D Table S2. List of ...
coli does not have genes analogous to the S. typhimurium supQ newD genes, of that, if present, activation of a newD is a rare event or is lethal to the cell. 展开 DOI: 10.1128/JB.137.3.1253-1262.1979 被引量: 17 年份: 1979
range from − 12 to + 7; approximately 15% of all variants, with GERP RS ≥ 2 are deemed to be “constrained” (marked in red).bDistribution of variants in constrained sites by category for coding and non-coding mutations (see the inset for the mutation type color code) ...