Cdc25 genes encode protein threonine/tyrosine phosphatases that activate cyclin-dependent kinases. A cDNA encoding the murine homologue of the human Cdc25C... W Shuang,DJ Wolgemuth - 《Developmental Biology》 被引量: 167发表: 1995年 Development of a unique system for spatiotemporal and lineage-sp...
Non-coding germline variants activate driver TEs during tumorigenesis We investigated whether any of the 9528 tumor triplets were constituted of any previously identified tumor-specific or shared TE-eQTLs and assess how the model likelihood changed between normal and tumor. We identified 320 and 133 ...
Pathogen-associated molecular patterns activate expression of genes involved in cell proliferation, immunity and detoxification in the amebocyte-producing ... The anterior pericardial wall of the snail Biomphalaria glabrata has been identified as a site of hemocyte production, hence has been named the am...
Analysis of the three rice homologs of the Arabidopsis BLADE-ON-PETIOLE1 (BOP1) gene indicates that OsBOPs activate proximal sheath differentiation and suppress distal blade differentiation. Temporal expression changes of OsBOPs are responsible for the developmental changes in the sheath:blade ratio. ...
and ERF, activate the expression of immune genes by targeting their promoters [14,15]. Additionally, some TFs, such as ARABIDOPSIS SH4-RELATED3 (ASR3), could function as transcription repressors to fine-tune immune gene transcription [16]. In particular, EPCOT3 was proven to be a bona fid...
Using multiple genes in one organism has allowed us to determine whether FGF signaling is required for the induction of multiple early neural genes independent of BMP inhibition, and also to determine the role of FGF8a in neural development. Using gain and loss of function assays, we show that...
selection, cells were induced with doxycycline (2 µg/mL) to activate dCAS9-KRAB. For dCas9 P300, the human myometrial hTERT cells were transduced with lentivirus carrying the LV-sgRNA plasmid targeting the lead SNP and Luciferase (control sgRNA) and selected with Zeocin (100 µg/...
Osteonecrosis of the femoral head (ONFH) is a multifactorial disease leading to severely limited function. By far, the etiology and pathogenesis of ONFH are not fully understood, and surgery is the only effective way to treat ONFH. This study aims to ide
However, under pathogenic conditions, the massive release of extracellular GLU can stimulate GLuR, induce inward calcium flow, and activate calcium-dependent death signaling pathways. In turn, GLU toxicity in cells and tissues is not immediately alleviated after resuscitation and may further exacerbate ...
In Arabidopsis, both MYB21 and MYC2 regulators were shown to activate the expression of sesquiterpene synthase genes, and the regulatory roles of AtMYB21 and AtMYC2 in the expression of the linalool synthase gene were also confirmed, implying conserved functions of the MYB–bHLH complex in ...