Development of the initial stages of pulmonary fibrosis associated with ageing in non-treated mice (left), that can be prevented in mice treated with the telomerase gene therapy (right). Credit: CNIO Idiopathic pulmonary fibrosis is a potentially lethal disease for which there is currently no cur...
Gene therapy utilizes nucleic acid drugs to treat diseases, encompassing gene supplementation, gene replacement, gene silencing, and gene editing. It represents a distinct therapeutic approach from traditional medications and introduces novel strategies for genetic disorders. Over the past two decades, sign...
ARVO LIVE: Epigenetic reprogramming to reverse aging and restore function to retinal ganglion cells ARVO LIVE: Ascidian Therapeutics' research into gene therapy Moving beyond the drop: CEO provides updates on Oyster Point's pipeline RNA-Seq analysis identifies cell subtypes to use as models for corne...
For gene therapy, suicide vectors are normally used so as to prevent the spread of the infection. To prepare the stock of virus lacking E1, the virus must be grown in a cell line that expresses E1. An overview of this process is shown in Fig. 11.2. The complementing cell line, which...
However, efficient vectors and novel therapeutic targets, as well as the huge unmet demand, would drive the development of gene therapy. For this review, we would like to emphasize the contributions and limitations of both viral and nonviral gene-delivering vectors, as well as several efforts ...
WASHINGTON, July 20 (Xinhua) -- A study published on Friday in the journal Cell Death & Disease showed that the mice developed with wrinkled skin and visible hair loss could be restored by turning off a gene, lending a clue for potential therapy against aging. ...
Towards gene therapy for cystic fibrosis airway disease: development of single-dose lentiviral gene transfer for lifetime airway expression. Towards gene therapy for cystic fibrosis airway disease: development of single-dose lentiviral gene transfer for lifetime airway expression.Cystic Fibrosis (CF) is...
Genomics of Drug Sensitivity in Cancer (GDSC; https://www.cancerrxgene.org/), which is used for molecular cancer therapy and mutation, was used to explore public databases [34]. R's pRRophetic package was used to download cell line gene mutation data and IC50 values of different anticancer...
Department of Clinical Gene Therapy, Osaka University Graduate School of Medicine, Suita, Japan Tomohiro Katsuya Department of Geriatric and General Medicine, Osaka University Graduate School of Medicine, Suita, Japan Tomohiro Katsuya Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of...
Specifically, the invention provides methods of gene therapy for treating erectile dysfunction, bladder dysfunction, and other smooth muscle disorders. The present invention also provides recombinant viral and non-viral vectors comprising DNA encoding a protein involved in the regulation of smooth muscle ...