P values were estimated by testing the null hypothesis of zero intercepts using an F test. P-adj, adjusted P value. Full size image In addition to separating genes by temporal dynamics, the coexpression networks also highlighted subpopulation-specific gene expression modules, corresponding to ...
Helping to drive interest in portable gene-therapy devices is a new form of cancer therapy, known as CAR-T, that reprograms the DNA of immune system sentinels called T cells so they attack tumors. A growing pack of biotech companies has ra...
j, Boxplots comparing intraclonal and interclonal correlation between clonally aggregated gene expression and gene activity scores in the reprogramming dataset (n = 29 clones used; Mann–Whitney–Wilcoxon test, two-sided; ***P = 5.16 × 10−4). Boxplots: center line, median...
Asterisks above the boxplots indicate a significant difference in substitution rate was found between the sex-biased and unbiased genes using Mann–Whitney U test for non-parametric distributions (*** p < 0.0001; *** p < 0.001; ** p <0.01; * p < 0.05). Full size image ...
The data revealed that essentially all F2 and HS4 modules had a counterpart in the HS-CC and vice versa (Fisher exact test), although some of the larger HS-CC modules fragmented into two or more F2 or HS4 modules. An examination of the unassigned "grey" genes across the three networks...
where each trait is a quantitative measure of mRNA level for a given gene or transcript across a set of individuals. With recent advances in cataloging common genetic variation in human populations (variants with minor allele frequency >5%), an eQTL study might test tens of millions of SNPs...
(#4) often occurs because researchers do not test a single variant but rather test many, which increases the likelihood of incorrectly identifying a statistically significant association. As such, gene discovery often employs more stringent p-values (Martin et al., 2007b). Unfortunately, it is ...
Current methods for analyzing single-cell datasets have relied primarily on static gene expression measurements to characterize the molecular state of individual cells. However, capturing temporal changes in cell state is crucial for the interpretation o
Finally, since this small, wild, annual grass has been widely adopted as a model system for the grasses used to produce grains, forage, and biofuels, numerous experimental resources exist to functionally test hypotheses developed from the analysis of its pan-genome19,22,23. Results De novo ...
Their study was published in the latest issue of Nature. "In future research, we plan to test whether other longevity genes also play a similar role in monkey, and continue our research to unravel the mechanism of human aging," Liu said....