We also discovered a processed pseudogene () which has 98.5% nt identity to, that needs to be accounted for in cDNA mutation analysis. Our findings suggest that genetic abnormalities of thegene are only involved in a relatively small subset of lung cancers....
Genetics: Gene mutation tied to lung cancerNo abstract is available for this article.doi:10.1002/scin.5591611618NoneSociety for Science & the PublicScience News
Clinical analysis of NSCLC patients reveals lack of association between EGFR mutation and TET1 downregulation J-I Lai , Y-C Lai & S-C Chang Original Article | 21 April 2017 lncRNA-HIT promotes cell proliferation of non-small cell lung cancer by association with E2F1 L Yu , F Fang ...
Impact of EGFR mutation analysis in non-small cell lung cancer. The discovery of mutations in the tyrosine kinase domain of the epidermal growth factor receptor (EGFR) gene in non-small cell lung cancer (NSCLC) accelera... H Yamamoto,S Toyooka,T Mitsudomi - 《Lung Cancer Journal of the In...
Thus, p51 mutation occurs only in a small subset of lung cancer. Expression of the p51 gene was detected in 23 of 43 cell lines by Northern blot analysis and 34 of 44 by reverse transcriptase-polymerase chain reaction (RT-PCR) analysis. Thus, p51 expression is low or absent in a subset...
2012. Mutation of the Nrf2 gene in non-small cell lung cancer. Mol. Biol. Rep. 39:4743- 4747. http://dx.doi.org/10.1007/s11033-011-1266-4.Y. Hu, Y. Ju, D. Lin, Z. Wang, Y. Huang, S. Zhang et al., "Mutation of the NRF2 gene in non-small cell lung cancer," Molecular...
in the lesions, such as TP53 site mutation, EGFR T790M drug-resistant mutation, c-Met amplification mutation, etc. This leads to temporal heterogeneity of tumors and induces drug resistance.In addition, the metastases at different sites may have different drug resistance mechanisms.With the ...
Mutation by definition refers to a permanent change in a coding region of the DNA sequence. Mutation can be beneficial or detrimental to the cell. Here mutation is being reviewed as detrimental to the cell. It is a well-known fact that mutations in the DNA sequence may trigger a cascade of...
K-ras and p53 mutations are an independent unfavourable prognostic indicator in patients with non-small-cell lung cancer We examined 159 consecutive cases of non-small-cell lung cancer (NSCLC) for a mutation at codon 12 of the K-ras gene and for a mutation of the p53 gene occ... Y Fuku...
METHODS: 156 patients with primary non-small cell lung cancer (NSCLC) diagnosed as metastatic carcinoma by EBUS-TBNA of hilar and/or mediastinal lymph nodes were enrolled. We evaluated the gene mutation status of EGFR, K-ras and p53. In addition, retrospective chart review was performed. EGFR...