This process of activation of genes to produce proteins is called gene expression.This activation leads to the creation ofmessenger RNA (mRNA), which acts as a template for building the proteins. Simply, gene expression is the flow of genetic information from gene to protein. Gene expression is...
Gene Expression Regulation refers to the process by which the human body adjusts the activity of genes in response to changes in nutrient levels. This regulation is controlled by hormones, which monitor the concentration of nutrients in the blood and selectively activate or deactivate specific genes...
Gene expression regulations by long noncoding RNAs and their roles in cancer - ScienceDirectLncRNAsLncRNA functionsLncRNA binding partnersmultiple types of CancerCancers are deadly diseases. The general mystery of carcinogenesis, primary and acquired drug resistance and distant organ metastasis are still ...
Using these two approaches, we induced site-specific demethylation at the Oct4 promoter and confirmed the up-regulation of Oct4 expression. Furthermore, we confirmed that the synergistic effect of DNA demethylation and other epigenetic regulations increased the expression of Oct4 significantly. Based ...
(t-test, p = 2.33E−9, 3.06E−43, and 2.25E−4, respectively; Fig.2b), as well as the metabolic gene expression of those local neighboring reactions (Fig.2c). These correlations suggest potential coordinated regulation of locally coupled neighboring reactions. Here, we develop a ...
Insulin-like growth factor 1 (IGF-1) is involved in regulations of reproductive functions in rats and mice. IGF-1 expression is regulated by estrogen in several reproductive organs including the uterus and ovary. Two types of estrogen receptor (ERα and ERβ) are expressed in mouse uteri and...
Code Issues Pull requests Code for the paper "Integrating regulatory DNA sequence and gene expression to predict genome-wide chromatin accessibility across cellular contexts" deep-learning genomics gene-regulation epigenetics chromatin-accessibiity Updated Jun 9, 2021 Jupyter Notebook Danko...
For an application example, we evaluated mRNA expression profiles over time upon corticosteroid stimulation in rats, thus incorporating corticosteroid kinetics/dynamics, literature-recorded pathways and transcription factor (TF) information. 展开 DOI: 10.1371/journal.pone.0105942 被引量: 6 ...
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These epigenetic amendments also implicate induction of small RNA (sRNA)-mediated fine-tuning of transcriptional and post-transcriptional regulations of gene expression. These tiny (19-24 nt) RNA species, particularly microRNAs (miRNAs) besides endogenous small interfering RNA (siRNA) have emerged as ...