Characterization of the molecular function of the human genome and its variation across individuals is essential for identifying the cellular mechanisms that underlie human genetic traits and diseases. The Genotype-Tissue Expression (GTEx) project aims to characterize variation in gene expression levels acr...
Journal of Nanobiotechnologyis calling for our collection on Advances in Nanomaterials for Gene Therapy and Genome Editing. Gene therapy and genome editing are at the forefront of modern medicine, with remarkable potential to impact the prevention, intervention, and diagnosis of a wide range of diseas...
2b). We then analyzed the editing efficiency and indel frequencies by Sanger and next-generation amplicon sequencing (NGS) (Fig. 2c, d). No editing was detected with sgRNA#1. sgRNA#2 and #3 were specific to the mutant allele, as they showed editing activity only in patient hiPSC. ...
Genome Editing: We welcome submissions within the field of gene editing, covering various document types, such as reviews, research papers, or short communications on the latest findings and translational research in this evolving area. The broad focus of this section encompasses Investigations into th...
Another GWAS with a more limited sample size was not able to identify loci at a genome-wide significant level [60]. The largest GWAS to date was recently performed by Pervjakova et al. [61], involving 5485 women with GDM and 347,856 controls without GDM. Utilizing a multi-ancestry meta...
Congratulations to Emmanuelle Charpentier and Jennifer Doudna for being the co-recipients of the 2020 Nobel Prize in Chemistry for their ground-breaking research on gene and genome editing! 19 June 2018 More opportunities to publish your research: ...
723 representative genome-based species, using a whole-genome average nucleotide identity (ANI) threshold of 95% and an aligned fraction (AF) threshold of 30% (Fig.2cand Supplementary Data1). Delineation of these species was genome-based and the term “species” will be used for conciseness....
The CRISPR system is a revolutionary genome editing tool that has the potential to revolutionize the field of cancer research and therapy. The ability to precisely target and edit specific genetic mutations that drive the growth and spread of tumors has
Alfalfa (Medicago sativa) is the most widely planted legume forage and one of the most economically valuable crops in the world. The periodic changes in its growth and development and abiotic stress determine its yield and economic benefits. Auxin contro
Cervical cancer is the fourth most common cancer in women. N6-dimethyladenosine (m6A) mRNA methylation is closely associated with cervical cancer. Using TCGA database, we studied the expression and mutation of m6A-related genes in cervical squamous cell