Though genome editing (GE) is a powerful technology, germline GE engineering is strongly objectionable for a huge ethical challenge. The after-effects of the genome-edited babies incident have been emerging in China, whether technology or ethics. It is very noticeable that th...
To characterize the consequences of natural genetic diversity on the proteome, here we combine a multiplexed, mass spectrometry-based method for protein quantification with an emerging outbred mouse model containing extensive genetic variation from eight inbred founder strains. By measuring genome-wide ...
Genetics, among other factors, is thought to be one of the main drivers of this variability [13,14,15]. Specifically, emerging evidence indicates that an individual’s weight loss trajectory throughout their lifespan has a significant genetic contribution [16] and recent genome-wide association ...
The genome is one of the primordial elements of the human being and is responsible for human identity and its transmission to descendants. The gene as such ought not be appropriated or owned by man. However, any sufficiently complete description of a gene should be capable of being protected ...
N(6)-methyladenine is incorporated into mammalian genome by DNA polymerase. Cell Res. 31, 94–97 (2021). Article CAS PubMed Google Scholar Johnson, T. B. & Coghill, R. D. The discovery of 5-methyl-cytosine in tuberculinic acid, the nucleic acid of the tubercle bacillus. J. Am. ...
Salinity is one of the major abiotic stresses in plant agriculture wordwide, and an excess amount of salt in the soil adversely affects plant growth, devel... H Shu,S Guo,Y Gong,... - 《Molecular Plant Breeding》 被引量: 8发表: 2013年 Potential impact of genome editing in world agricu...
Finally, we will use CRISPR-dCas9 epigenome editing to investigate whether precisely altered DNA methylation levels change gene regulation of individual genes. At its conclusion, the proposed work will generate the first systematic assessment of the regulatory consequences of early adversity-associated ...
Lastly, we would like to thank Victoria Grace (www.english-publications.com) for editing the manuscript. This paper is publication BRC 351 of the Biodiversity Research Center (Université catholique de Louvain).Cited by (8) Cytochrome b Mitochondrial Gene Revealed a Strong Genetic Differentiation ...
Pan-genome The set of all of the genes that are found in members of a single species. Parasite An organism that diminishes the reproductive fitness of another organism or benefits from another organism without reciprocity. Pathogen In medicine, any organism that causes disease. In biological terms...
cells at a gene network level. When the researchers tested two of the proposed targets in cells affected by cardiomyopathy (a disease of the heart muscle), they indeed found that removing the predicted genes using CRISPR gene editing technology restored the beating ability of diseased cardiomyocytes...