人凝溶胶蛋白（Gelsolin）酶联免疫分析试剂盒使用说明书 本试剂盒仅供研究使用 检测范围：7.8ng/ml-500ng/ml 最低检测限：1.95ng/ml 特异性：本试剂盒可同时检测天然或重组的人凝溶胶蛋白，且与其他相关蛋白无交叉反应。有效期：6个月 预期应用：ELISA法定量测定人血清、血浆、细胞培养上清或其它相关生物液体中...
研究发现,血小板骨架蛋白凝溶胶蛋白(Gelsolin)是冠心病血瘀证与非血瘀证患者的血小板差异蛋白之一,其含量 在冠心病血瘀证患者血小板中明显增多,提示血小板骨架蛋白的异常表达在冠心病血瘀证发生发展中可能起到关键作用。 梗死后心肌组织 释放大量肌动蛋白微丝(F-actin)对内皮细胞和微血管产......
Gelsolin is an actin-binding protein that is a key regulator of actin filament assembly and disassembly. Gelsolin is one of the most potent members of the actin-severing gelsolin/villin superfamily, as it severs with nearly 100% efficiency. Gelsolin is located intracellularly (in cytosol and ...
3.1. Cloning of a new house dust mite antigen cDNA homologous to the gelsolin family Immunoscreening of the D. farinae cDNA library (1.38×107 clones) with rabbit anti-Dfb serum yielded 273 positive clones, and subsequent cross-hybridization analysis classified these cDNAs into nine groups (group...
Gelsolin Binding to Phosphatidylinositol 4,5-Bisphosphate Is Modulated by Calcium and pH The actin cytoskeleton of nonmuscle cells undergoes extensive remodeling during agonist stimulation. Lamellipodial extension is initiated by uncapping of a... KM Lin,E Wenegieme,PJ Lu,... - 《Journal of Biolo...
The actin-binding protein, gelsolin, is a well known regulator of cancer cell invasion. However, the mechanisms by which gelsolin promotes invasion are not well established. As reactive oxygen species (ROS) have been shown to promote cancer cell invasion, we investigated on the hypothesis that ge...
Gelsolin regulates the dynamic assembly and disassembly of the actin-based cytoskeleton in non-muscle cells and clears the circulation of filaments released following cell death. Gelsolin is a six-domain (G1-G6) protein activated by calcium via a multi-step process that involves unfolding from a...
Kinetics of Gelsolin Interaction with Phalloidin-Stabilized F-Actin. Rate Constants for Binding and Severing The kinetics of gelsolin interaction with actin filaments have been investigated using two fluorescent probes, tetramethylrhodamine isothiocyanate-labeled ... HJ Kinosian,Lynn A. Selden,James E. ...
Pig plasma gelsolin forms a ternary complex with monomeric actin in 0.1 mM CaCl2 and a binary complex in EGTA (<0.01 μM calcium), as shown by gel filtration and fluorescence changes when actin which had been treated with N-ethylmaleimide and 7-chloro-4-nitrobenzeno-2-oxa-1,3-diazole (...
Intriguing self-assembly of large granules of F-actin facilitated by gelsolin and alpha-actinin. Intriguing self-assembly of large granules of F-actin facilitated by gelsolin and alpha-actinin.MECHANICAL-PROPERTIESCROSS-LINKING JX Tang,HR Kang,JF Jia - 《Langmuir the Acs Journal of Surfaces & ...