The structure of G6 in the absence of Ca2+(PDB ID: 3FFN) (a) and in the presence of Ca2+(shown as black sphere), (PDB ID: 1P8X) (b). Upon Ca2+binding, the central long helix is straightened. The schematic representations are shown in rainbow colours from blue (N termini) to r...
1 A) and actin (Fig. 1 I) is shown. Actin distribution is seen at the periphery as a ring-like structure at the resorbing area. The formation of actin ring is a prerequisite for the initiation of bone resorption. Osteoclasts stained for gelsolin/actin (Fig. 1 I) and actin/αvβ3 (...
A number of studies aiming to evaluate the structure and cellular functions of gelsolin-related proteins demonstrated that adseverin shares 60% amino acid homology with gelsolin (but lacks a C-terminal helix found in gelsolin), whereas flightless I, villin, advillin, and supervillin are ...
Chronic kidney disease (CKD) is normally related to proteinuria, a common finding in a compromised glomerular filtration barrier (GFB). GFB is a structure composed of glomerular endothelial cells, the basement membrane, and the podocytes. CKD with podocyte damage may be associated with actin cytoske...