GDP-fucose transporter 1 (SLC35C1)GDP-fucose is used by fucosyltransferases in both the Golgi and endoplasmic reticulum (ER). As it is synthesized in the cytoplasm, transport into the lumen of the secretory pathway organelles is required. The first indication that GDP-fucose, like other ...
Here we identify GDP-fucose transporter 1 (GFT1), an Arabidopsis nucleotide sugar transporter that translocates GDP- L -fucose into the Golgi lumen. Using proteo-liposome-based transport assays, we show that GFT preferentially transports GDP- L -fucose over other nucleotide sugars in vitro , ...
The gene encoding the GDP-fucose transporter was identified independently by two groups using complementation cloning in patient-derived cells (Lübke et al. 2001; Lühn et al. 2001). These patients were suffering from leukocyte adhesion deficiency II (LAD II), also known as congenital disorder ...
32 Chen et al recently suggested that a multi–transmembrane protein termed SLC35C2 (gene CGI-15/Ovcov1) might transport GDP-fucose into the ER but expression of this protein reduced the Golgi-based fucosylation of Lex arguing against SLC35C2 to be the alternative transporter.33 Thus, the ...
In humans, the mutation of a GDP-fucose transporter is responsible for an impaired immune response as well as retarded growth. These results suggest that, even though there appear to be a fair number of genes encoding for NSTs, ... M Handford,C Rodriguez-Furlán,A Orellana - 《Brazilian ...
Lubke T, Marquardt T, Etzioni A, Hartmann E, von Figura K, Korner C. Complementation cloning identifies CDG-IIc, a new type of congenital disorders of glycosylation, as a GDP-fucose transporter deficiency. Nat Genet 28:73-76, 2001.
WbgL: a novel bacterial ±1,2-fucosyltransferase for the synthesis of 2'-fucosyllactose.###FX enzyme and GDP-L-Fuc transporter expression in colorectal ca... expression profiles of the FX enzyme and GDP-L-Fuc Tr in a cohort of operated CRC patients to elucidate their role in 卤(1,6)fuc...
( 2000 ) GDP-fucose uptake into the Golgi apparatus during xyloglucan biosynthesis requires the activity of a transporter-like protein other than the UDP-glucose transporter . Plant Physiol. 122 , 867 – 877 .Wulff C , Norambuena L , Orellana A . 2000 . GDP-fucose uptake into the Golgi ...
1Anna1Liu1Li1EBSCO_AspPlos OneXu YX, Ma A, Liu L. Transforming growth factor beta signaling upregulates the expression of human GDP-fucose transporter by activating transcrip‑ tion factor Sp1. PLoS One. 2013;8:e74424.Y.X. Xu, A. Ma, L. Liu, Transforming growth factor beta ...
Nucleotide sugar transport across Golgi membranes is essential for the luminal biosynthesis of glycan structures. Here we identify GDP-fucose transporter 1 (GFT1), an Arabidopsis nucleotide sugar transporter that translocates GDP-L-fucose into the Golgi