CONCLUSION: This study adds evidence the GDF15-GFRAL-RET complex is involved in the etiology of HG. HG is associated with increased risk of adverse outcomes, including maternal suicidal ideation, post-traumatic stress disorder, preterm birth, and neurodevelopmental delay in offspring. Current ...
Targeting both sides of the GDF15-GFRAL-RET receptor complex: A new approach to achieve body weight homeostasisAnorexia, Brain, GDF15, GFRAL, MIC-1, Obesity, RETObesity is a chronic, complex disease, which is associated with several comorbidities, including diabetes mellitus, hypertension, and ...
We also found that GDF-15 inhibits ADP-induced AKT and ERK activation in platelets. Meanwhile, our results revealed that the inhibitory effects of GDF-15 can be mediated by the GFRAL/RET complex. These findings reveal the novel inhibitory mechanism of ADP-induced platelet activatio...
GDF15-GFRAL-RET receptor signaling complex is involved in stress/disease-induced anorexia will certainly impact our knowledge of body weight homeostasis under healthy and disease conditions.Based on this breakthrough,a new class of GFRAL/RETbased drugs is highly anticipated for the treatment of ...
We also found that GDF-15 inhibits ADP-induced AKT and ERK activation in platelets. Meanwhile, our results revealed that the inhibitory effects of GDF-15 can be mediated by the GFRAL/RET complex. These findings reveal the novel inhibitory mechanism of ADP-induced platelet activation by GDF-15....