Mitochondria are multifunctional organelles that regulate diverse cellular processes. Mitochondrial stress, including stress generated by electron transport chain defects and impaired mitochondrial proteostasis, is intimately involved in various diseases and pathological conditions. Sepsis is a life-threatening ...
• 线粒体衍生肽( mitochondria-derived peptides ,MDPs) 线粒体衍生肽是线粒体DNA的小开放阅读框编码的微蛋白质(即由少于100个氨基酸组成的生物活性肽),已经发现八种线粒体衍生肽(humain/HN,MOTS-c,SHLPs 1–6)。 HN是一种由线粒体 16s rRNA 基因编码的 24 个氨基酸多肽,在心脏、大脑、肝脏、结肠、...
However, it is established that this condition induced an oxidative stress with production of reactive oxygen species [88], at least, in renal tubular cells like the principal cells of the collecting duct, which may suggest a dysfunction of the mitochondria. Of note, mitochondria dysfunction has ...
Mitochondria and critical illness[J]. Chest, 2020,157(2):310-322. DOI: 10.1016/j.chest.2019.08.2182 . 返回引文位置Google Scholar 百度学术 万方数据 [8] Zhong J , Tan Y , Lu J ,et al. Therapeutic contribution of melatonin to the treatment of septic cardiomyopathy: a novel mechanism ...
GDF15信号传导的治疗性抑制剂.pdf,本发明涉及结合至胶质细胞源性神经营养因子家族受体α样(GFRAL)蛋白并抑制其活性的抗体。本发明还涉及作为恶病质状态以及涉及食物摄入减少和肌肉和脂肪量减少的病症的治疗靶标的GDF15‑GFRAL信号传导通路。(19)国家知识产权局 (12)发明专
The role of mitochondria in insulin resistance and type 2 diabetes mellitus. Nat. Rev. Endocrinol. 8, 92–103 (2011). Article PubMed CAS Google Scholar Lawrence, R. E. & Zoncu, R. The lysosome as a cellular centre for signalling, metabolism and quality control. Nat. Cell Biol. 21,...
elegans where an induction of the mitochondrial unfolded protein response (UPRmt) in neurons led to changes in mitochondria within physically distinct, non-innervated tissues (Durieux et al., 2011), but has more recently been supported by evidence linking FGF21 to the ISR (Salminen et al., ...
et al. Mitochondrial energy deficiency leads to hyperproliferation of skeletal muscle mitochondria and enhanced insulin sensitivity. Proc. Natl. Acad. Sci. USA 114, 2705–2710 (2017). Article CAS Google Scholar Chung, H.K. et al. Growth differentiation factor 15 is a myomitokine governing ...
5C-E). Mitochondrial potential detection with JC-1 illustrated that MP treatment decreased the mitochondrial potential (P < 0.01), indicating that mitochondria were destroyed (Fig. 5F). When the BMSC was treated with MT, the mitochondrial potential was recovered (P < 0.05) (Fig. 5F,...
Background Mitochondria is a key organelle for energy production and cellular adaptive response to intracellular and extracellular stresses. Mitochondrial stress can be evoked by various stimuli such as metabolic stressors or pathogen infection, which may lead to expression of 'mitokines' such as ...