如本文所述的GDF11多肽可以包含通常存在于多肽和/或由 活生物体产生的蛋白质中的天然存在氨基酸,例如Ala (A)、Val (V)、Leu (L)、Ile (I)、Pro (P)、Phe(F)、Trp(W)、Met(M)、Gly(G)、Ser(S)、Thr(T)、Cys(C)、Tyr(Y)、Asn(N)、Gin(Q)、Asp (D)、Glu(E)、Lys(K)、Arg (R)和His(...
rGDF11治疗这些内皮细胞激活TGF-β信号通路,从而刺激 Smad的磷酸化级联反应。但原发性脑毛细血管的治疗与rGDF11内皮细胞增殖相比增加与对照组不在一个TGF-β抑制剂的存在,从而证实GDF11对这些细胞的直接生物学效应通过Smad通路(katsimpardi 等人,2014)。 有证据表明,骨骼肌影响系统老化,但很少有已知的信号通路。
激活素与激活素IIA型(ActRIIA)或IIB型(ActRIIB)受体的结合诱导激活素I型受体的募集和磷酸化,然后磷酸化Smad2和Smad3细胞内信号蛋白[12]。GDF15上调是由于GDF11诱导SMAD2/3向GDF15启动子募集所致。抑制GDF15可以恢复食欲,但不能恢复GDF11诱导的肌肉质量损失,这需要阻断ActRII信号。关于GDF11诱导GDF15的机制,研究...
Next, we compared the dendritic spines of the EN at high magnification (WT: n = 16; KO: n = 16) and found that loss of GDF11 impeded their spine morphology in two ways. Firstly, knocking-out GDF11 decreased the spine density (Fig. 5q, r). Secondly, it surprisingly enlarg...
Karppinen S-M, Heljasvaara R, Gullberg D, Tasanen K, Pihlajaniemi T. Toward understanding scarless skin wound healing and pathological scarring. F1000Research. 2019;8:787. Google Scholar Soehnlein O, Lindbom L. Phagocyte partnership during the onset and resolution of inflammation. Nat Rev Imm...
R54 单位代码 : 10335 密 级 : 学 号 : 1 1418146 博士学位论文 中文论文题目 : GDF11在压力超负荷诱导小鼠心肌肥 厚中的作用及其机制研究 英文论文题目 : The role and mechanisms of GDF11 in pressure overload - induced cardiac hypertrophy 申请人姓名 ** 朱锦云 J旨导教师 : ...
R GAGAGGTCCACAGAGCTGATT R TGCACTTTGGTACTCTTGAAGTT Plin1 F CAAGCACCTCTGACAAGGTTC PLIN1 F TGTGCAATGCCTATGAGAAGG R GTTGGCGGCATATTCTGCTG R AGGGCGGGGATCTTTTCCT Plin2 F GACCTTGTGTCCTCCGCTTAT PLIN2 F ATGGCAGAGAACGGTGTGAAG2 R CAACCGCAATTTGTGGCTC R CAACTGCAATTTGCGGCTC Plin5 F TGTCCAGTG...
(P=0.078). Von Kossa staining further confirmed the loss of trabecular bone in high-dose rGDF11 mice (Fig. 1b). Histomorphometric analysis revealed a significant increase in osteoclast number (N.Oc/B.Pm) and a decrease in osteoblast number (N.Ob/B.Pm;Fig. 1c,d). Meanwhile, the ...
Jorgensen JA, Zadravec D, Jacobsson A. Norepinephrine and rosiglitazone synergistically induce Elovl3 expression in brown adipocytes. Am J Physiol Endocrinol Metab. 2007;293(5):E1159–68. https://doi.org/10.1152/ajpendo.00213.2007. Article CAS PubMed Google Scholar Westerberg R, Mansson JE, Go...
It was found that rGDF11 was able to reduce the levels of AGEs, protein oxidation and lipid peroxidation, and to slow down the accumulation of age-related histological markers, while rGDF8 was not. Moreover, rGDF11 significantly prevented the decrease in CAT, GPX and SOD activities, but ...