GDF11的90%的氨基酸序列与肌肉生长抑制素是完全相同的。(Dschietzig,2014)。 正如我们前面提到的,TGF-β超家族成员的信号通过一个有跨膜丝C)氨酸激酶、跨膜苏氨酸激酶的Ⅰ型受体和Ⅱ型受体的组合。GDF11与Ⅰ型受体相互作用:ALK(1-7),例如:ALK-4(ACVR1B)、ALK-7(ACVR1C),和Ⅱ型激活素受体(Ⅱ型受体:...
GDF11 is expressed in the excitatory neurons of the adult brain The specificity of 4 anti-GDF11 antibodies was carefully characterized here (Supplementary Fig. 1a–d and Supplementary Table 1) and partially in previous studies15,16, and was further validated by using the cerebral cortices of the...
500 μm. (c) TRAP staining of femur sections from vehicle and rGDF11 treated mice. Scale bar, 50 μm. (d) Histomorphometric analysis of the metaphysis region of distal femurs. Results are shown as mean
On the second floor, dedicated to 3C products, flocks of customers congregated inside the Huawei and Apple stores, shopping for smart phones, smart watches, laptops and high-end headphones. The display counters of the Hu...
In this study, we first demonstrated that when recombinant GDF8 (rGDF8) and GDF11 (rGDF11) of the fish Nothobranchius guentheri were injected into 20-month-old male mice, their serum GDF8 and GDF11 levels were clearly increased. We also showed关键词: GDF11 Aging Mice Nothobranchius GDF8 ...
总体(gdf11和激活素)结合活性可以通过包含“尾部”区域或推测地非结构化的接头区域,以及也通过应用k74a突变而增加。引起配体结合亲和力的总体降低的其它突变包括:r40a、e37a、r56a、w78a、d80k、d80r、d80a、d80g、d80f、d80m和d80n。突变可组合以实现期望的效果。例如,影响gdf11:激活素结合比的许多突变对配体...
近期研究表明,GDF11、GDF15等生长因子在急性肝损伤过程中发挥重要作用。 研究的张Y,李问刘D,黄问,Cai G,崔年代,陈太阳X, X等肾脏等表明GDF11/8随年龄和GDF11能增加肾小管细胞去分化和增殖以及提升管再生后急性肾损伤(AKI)老老鼠。(2) GDF11在体内外均显著激活ERK1/2,增加下游因子cyclin D1和c-Myc的...
a Serum concentration of GDF11 as function of time post plasmid injection; b relative mRNA levels of Gdf11 in the liver 8 weeks post plasmid injection; c serum levels of AST and ALT at the end of experiments; d growth curve; e representative images of mice at end of the experiment; f...
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Brown, D. A. et al. MIC-1 serum level and genotype: associations with progress and prognosis of colorectal carcinoma. Clin. Cancer Res. 9, 2642–2650 (2003). CAS PubMed Google Scholar Lambert, J. R. et al. Reduced expression of GDF-15 is associated with atrophic inflammatory lesions ...