(r=-0.437,-0.430,-0.306,均P<0.05),与骨髓有核红细胞 比例,Ret百分比,MCV和骨髓CD235a的表达呈正相关(r=0.465,0.392,0.505,0.387,P<0.05),与MCHC和 MCH无相关性(均P >0.05).低危组MDS患者外周血GDF11浓度与骨髓CD235a的表达呈正相关(r=0.429,P<0.05),与外周血Hb,RBC,Ret 百分比,MCV,MCH,MCHC,...
如本文所述的GDF11多肽可以包含通常存在于多肽和/或由 活生物体产生的蛋白质中的天然存在氨基酸,例如Ala (A)、Val (V)、Leu (L)、Ile (I)、Pro (P)、Phe(F)、Trp(W)、Met(M)、Gly(G)、Ser(S)、Thr(T)、Cys(C)、Tyr(Y)、Asn(N)、Gin(Q)、Asp (D)、Glu(E)、Lys(K)、Arg (R)和His(...
目的 探讨外源性予以重组生长转化因子11(r-GDF11)对SD大鼠动脉血管钙化的影响.方法 将SD大鼠分为钙化组、溶媒组、低浓度组、中浓度组、高浓度组5组,适应性饲养1周后,每日分别予以腹腔注射生理盐水、r-GDF11溶媒液及低、中、高浓度r-GDF11,持续7周后开始诱导钙化.诱导钙化7周后取各组大鼠血液,分离其...
rGDF11补充老龄小鼠提高了卫星的再生能力细胞.近年来的研究发现,GDF11是有年轻的再生潜力的体液调节,并表明,恢复通过GDF11是老化卫星细胞功能与逆转积累的DNA损伤(Sinha等人,2014)。 TGF-β家族成员进行复杂的调控,由于许多蛋白质能够结合的配位体,并抑制其活动已经确定(Souza 等人,2008)。这些结合之一蛋白质是GDF...
Zeisberg M, Kalluri R. Cellular mechanisms of tissue fibrosis. 1. Common and organ-specific mechanisms associated with tissue fibrosis. Am J Phys Cell Phys. 2013;304:C216–25. CASGoogle Scholar Gabbiani G. The myofibroblast in wound healing and fibrocontractive diseases. J Pathol. 2003;200:500...
低危组MDS患者外周血GDF11浓度与骨髓CD235a的表达呈正相关( r=0.429, P<0.05),与外周血Hb、RBC、Ret百分比、MCV、MCH、MCHC、Hct及骨髓有核红细胞比例均无相关性(均 P>0.05)。(4) RT-PCR方法检测GDF11基因的表达:MDS组GDF11 mRNA表达水平高于健康对照组(39.82±14.55比1.84±0.64),差异有统计学意义( P<...
We first examined the role of GDF11 in bone remodelling by administering young adult mice (9 week old) with daily intraperitoneal injections of rGDF11 (0.1 or 0.3 mg kg−1body weight; #120-11, PeproTech, Rocky Hill, NJ) or vehicle (saline) for 6 weeks. MicroCT analysis of ...
11 Circulating GDF11 was found to decline with age, and restoration of GDF11 levels by recombinant GDF11 (rGDF11) injections in aged mice restored muscle integrity, reversed pathologic cardiac hypertrophy, and induced vascular remodeling and neurogenesis in the brain.11, 12, 13 In its active ...
It was found that rGDF11 was able to reduce the levels of AGEs, protein oxidation and lipid peroxidation, and to slow down the accumulation of age-related histological markers, while rGDF8 was not. Moreover, rGDF11 significantly prevented the decrease in CAT, GPX and SOD activities, but ...
R GAGAGGTCCACAGAGCTGATT R TGCACTTTGGTACTCTTGAAGTT Plin1 F CAAGCACCTCTGACAAGGTTC PLIN1 F TGTGCAATGCCTATGAGAAGG R GTTGGCGGCATATTCTGCTG R AGGGCGGGGATCTTTTCCT Plin2 F GACCTTGTGTCCTCCGCTTAT PLIN2 F ATGGCAGAGAACGGTGTGAAG2 R CAACCGCAATTTGTGGCTC R CAACTGCAATTTGCGGCTC Plin5 F TGTCCAGTG...