To determine the contribution of different IL-17A expressing T cell subsets, we next used flow cytometry to assess IL-17A and IFN-g expression in gd, CD4, and CD8 T cells in each of the four experimental groups.
Although gd T cells recognize target cells in an MHC-independent fashion, consistent with a lack of surface CD4/CD8ab co-receptor expression, the key paradigms underpinning their distinct immunobiology are unclear. Mouse studies have highlighted gd T cell subsets bearing semi-invariant TCRs1,3–5,...
Mechanistically, we find that loss of IL-33 impairs recruitment of gd (gamma delta) T cells but not CD4+ T cells that express the IL-33 receptor ST2 in the skin. Furthermore, gene deficient mice that lack all gd T cells show impaired immunity against S. ratti indicating an essential ...
The Immunology of Giant Cell Arteritis. Circ Res. 2023 January 20; 132(2): 238–250. doi:10.1161/CIRCRESAHA.122.322128 高危个体出生时就有遗传风险决定因素,主要发生在HLA。发病过程有3个检查点: 检查点1:区分免疫表型(...
1 Notably, among T cells, the γδ T-cell receptor (TCR)-expressing subclass of lymphocytes (γδ T cells) have garnered considerable attention in recent years due to their roles in tumor inhibition and the unique attributes possessed by these cells that not only distinguishes them from αβ...
We then used Jurkat cells (a human CD4+ T cell line) to dissect the IpgD-mediated molecular mechanism involved in the impairment of T cell migration observed in the activated primary human CD4+ T cells. We first assessed whether, upon Shigella infection, Jurkat cells displayed the same phenot...
目的:检测三组散发型白癜风患者治疗前后外周血CD4+/CD8+T细胞比值及CD4+CD25+调节性T细胞水平,评价三种治疗方案对散发型白癜风免疫功能的影响。方法:将76例患者随机分为三组:治疗①组:单用吡美莫司治疗;治疗②组:吡美莫司联合中药方剂治疗;治疗③组:吡美莫司联合
[1]Littman DR,Rudensky AY.Th17 and regulatory T cells in mediating and restraining inflame-Mation[J].Cell,2010,140(6):845-858.[2]Visekruna A,Huber M,Hellhund A,et al.c-Rel is crucial for the induction of Foxp3(+) r-egulatory CD4(+) T cells but not T(H)17 cells[J].Eur J ...
蛋白别名: T-cell immunoreceptor with Ig and ITIM domains; tigit; V-set and transmembrane domain containing 3; V-set and transmembrane domain-containing protein 3 基因别名: ENSMUSG00000071552; Vstm3 Entrez Gene ID: (Mouse) 100043314 功能 receptor binding 参与通路 negative regulation of int...
T cells suppressed allograft rejection mediated by memory CD4 þ T cells via a CD30-dependent mechanism.22,23 We recently found that CD30L/CD30 signaling executed by T/T cell interaction plays a critical role in Th1 and Th17 cell differentiation in vitro and in vivo.24–26 Thus, CD30L...