Bonafe, N. et al. Glyceraldehyde-3-phosphate dehydrogenase binds to the AURich 3-untranslated region of colony-stimulating factor-1 (CSF-1) messenge RNA in human ovarian cancer cells: possible role in CSF-1 posttranscriptiona regulation and tumor phenotype. Cancer Res. 65, 3762–3771 (2005)....
GAPDH is overexpressed in many cancers (Chiche et al., 2015; Liberti et al., 2017; Revillion et al., 2000), but is role in tumorigenesis is still unclear (Revillion et al., 2000). 2000年的时候人家就说GAPDH在肿瘤中高表达,就像这篇文章的结论,在血管免疫母细胞性淋巴瘤老鼠模型中GAPDH是高...
and potential as drug delivery vehicles. Here we demonstrate a role for the glycolytic enzyme glyceraldehyde-3-phosphate dehydrogenase (GAPDH) in EV assembly and secretion. We observe high levels of GAPDH binding to the outer...
et al., 2000), but is role in tumorigenesis is still unclear (Revillion et al., 2000).2000年的时候人家就说GAPDH在肿瘤中高表达，就像这篇文章的结论，在血管免疫母细胞 性淋巴瘤老鼠模型中GAPDH是高表达的。而这样的表达会参与NF-κB通路的激活。基因一旦跟 这个通路连上，一定不干好事。下面的故事就...
GAPDH may also play a role in neurodegenerative pathologies such as Huntington and Alzheimer's diseases (4,5). Barber, R.D. et al. (2005) Physiol. Genomics 21, 389-95. Hara, M.R. and Snyder, S.H. (2006) Cell Mol. Neurobiol. 26, 527-38. Zheng, L. et al. (2003) Cell 114,...
GAPDH is overexpressed in many cancers (Chiche et al., 2015; Liberti et al., 2017; Revillion et al., 2000), but is role in tumorigenesis is still unclear (Revillion et al., 2000). 2000年的时候人家就说GAPDH在肿瘤中高表达,就像这篇文章的结论,在血管免疫母细胞性淋巴瘤老鼠模型中GAPDH是高...
BackgroundGAPDH (Glyceraldehyde-3-phosphate dehydrogenase) has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. It participates in nuclear events including transcription, RNA transport, DNA replication and apoptosi...
and DNA repair. During the last decade a lot of data appeared concerning the role of GAPDH in different pathologies including prostate cancer progression, programmed neuronal cell death, age related neuronal diseases, such as Alzheimer's and Huntington's disease. GAPDH is expressed in all cells. ...
GAPDH plays a major enzymatic role in the intermediary metabolism of human tissues. In fact, the cells of all organisms require the catalytic capability of GAPDH in order to maintain adequate glycolytic flux. Even the primitive archaea rely on GAPDH in a pivotal step in the Entner-Doudoroff ...
During the last decade a lot of data appeared concerning the role of GAPDH in different pathologies including prostate cancer progression, programmed neuronal cell death, age related neuronal diseases, such as Alzheimer's and Huntington's disease. GAPDH is expressed in all cells. It is ...