Gamma-secretase inhibitorsUrea derivatives of formula I are disclosed: The compounds are inhibitors of γ-secretase, and hence useful in the treatment or prevention of Alzheimer's DiseaseJose Luis Castro PineiroAdrian Leonard SmithGraeme Irvine Stevenson...
Targeting Intrinsically-Resistant Breast Cancer Stem Cells with Gamma-Secretase Inhibitors Background: We showed previously that tumorigenic, mammosphere-forming human breast cancer cells characterized by high CD44 and low or undetectable CD24 levels (CD44 + /CD24 -/low ) are intrinsically resistant to...
4.1 Gamma secretase inhibitors Gamma secretase inhibitors (GSIs) have long been investigated for their potential as Alzheimer's disease (AD) treatments due to their ability to block secretion of amyloid β-peptide, the precursor of amyloid plaques associated with AD. The integral role that γ-secre...
3.2.8 Gamma-secretase inhibitors Interesting evidence indicates that sub-chronic treatment (twice-a-day for 12 days) and acute administration of semagacestat (LY-450139), a gamma-secretase inhibitor, at a dose that reduces Aβ levels produces a reduction in power of hippocampal θ activity elici...
GAMMA-SECRETASE INHIBITORS 专利名称：GAMMA-SECRETASE INHIBITORS 发明人：Mori, Hiroshi 申请号：EP03720938.4 申请日：20030418 公开号：EP1498421A1 公开日：20050119 专利内容由知识产权出版社提供 摘要：Disclosed, as a γ-secretase inhibitor, is a compound consisting of an amino acid sequence which ...
发明名称: Gamma-secretase inhibitors 发明人: JOSE LUIS CASTRO PINEIRO;TIMOTHY HARRISON;PETER ALAN HUNT;ALAN JOHN NADIN 申请人: 申请日期: 2001-01-19 申请公布日期: 2005-02-17 代理机构: 代理人: 地址: 摘要: 二、法律状态 暂无信息 三、权利要求 暂无信息 登录查看更多 打开APP,查看更多专利的...
GAMMA-SECRETASE INHIBITORS 专利内容由知识产权出版社提供 专利名称:GAMMA-SECRETASE INHIBITORS 发明人:CASTRO PINEIRO, Jose, Luis,HARRISON, Timothy,HUNT, Peter, Alan,NADIN, Alan, John 申请号:GB2001000200 申请日:20010119 公开号:WO01/053255P1 公开日:20010726 摘要:Gamma-secretase inhibitors, useful in ...
GAMMA-SECRETASE INHIBITORS 专利名称：GAMMA-SECRETASE INHIBITORS 发明人：CASTRO PINEIRO, Jose, Luis,SMITH, Adrian, Leonard,STEVENSON, Graeme, Irvine 申请号：GB2001000855 申请日：20010228 公开号：WO01/066564P1 公开日：20010913 专利内容由知识产权出版社提供 摘要：Novel urea derivatives of formula (I) ...
目的探讨γ泌肽酶抑制剂在肺泡Ⅱ型上皮细胞(AECⅡ)与肺成纤维细胞(LF)共培养胎鼠模型中对Notch信号分子表达的影响。2) γ-secretase inhibitors γ-分泌酶抑制剂 1. Research on Computer-Aided Drug Design, Synthesis and Initial Activity Evaluation of γ-Secretase Inhibitors with Neuroprotective Effect; 兼...
Gamma-secretase inhibitors 专利名称：Gamma-secretase inhibitors 发明人：Jose Luis Castro Pineiro,Ian James Collins,Timothy Harrison 申请号：US10982586 申请日：20041105 公开号：US20050143369A1 公开日：20050630 专利内容由知识产权出版社提供 摘要： Compounds of formula I: inhibit gamma-secretase and hence ...