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Alzheimer's disease (AD) is a debilitating mental disorder involving severe cognitive impairment. Over 10 million people are afflicted with AD, resulting in hea...
Inhibition of gamma-secretase presents a direct target for lowering Aβ production in the brain as a therapy for Alzheimer's disease (AD). However, gamma-secretase is known to process multiple substrates in addition to amyloid precursor protein (APP), mo
gamma-secretase, Alzheimer, amyloid 来自 leaddiscovery.co.uk 喜欢 0 阅读量: 39 作者:LF Wang,R Zhang,X Xie 收藏 引用 批量引用 报错 分享 全部来源 求助全文 leaddiscovery.co.uk 站内活动 0关于我们 百度学术集成海量学术资源,融合人工智能、深度学习、大数据分析等技术,为科研工作者提供全面快捷的学术...
2,3,4,5-TETRAHYDROBENZOiF枚i1,4枚OXAZEPIN-5-CARBONS脛UREAMID DERIVATE ALS GAMMA-SECRETASE INHIBITOREN ZUR BEHANDLUNG VON ALZHEIMER 2,3,4,5-TETRAHYDROBENZOiF枚i1,4枚OXAZEPIN-5-carboxylic acid amide derivatives as GAMMA-secretase INHIBITORS FOR THE TREATMENT OF ALZHEIMER...
Modulation of the gamma-secretase enzyme, which reduces the production of the amyloidogenic Aβ42 peptide while sparing the production of other Aβ species, is a promising therapeutic approach for the treatment of Alzheimer's disease. Satori has identified a unique class of small molecule gamma-se...
(PS1), a subunit of γ-secretase involved in amyloid-β (Aβ) peptide production, and GLT-1, the major brain glutamate transporter (EAAT2 in the human), may link two pathologi- cal aspects of Alzheimer's disease: abnormal Aβ occurrence and neuronal network ...
The amyloid- peptide (A) is the major protein component of the characteristic cerebral plaques of Alzheimer's disease (AD), and a large body of evidence supports a pathogenic role for this peptide. Thus, the proteases - and -secretase that are responsible for carving Ab out of its precursor...
Pept. Sci. 1(2):132-139 (Mar./Apr. 1995).Evin, et al., " A Synthetic Substrate Assay for the Gamma-Secretase of the β-A4 Amyloid of Alzheimer's Disease, " J. Pept. Sci. 1(2):132-139 (Mar./Apr. 1995).