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Phase II safety trial targeting amyloid beta production with a gamma-secretase inhibitor in Alzheimer's disease LY450139 was generally well tolerated at doses of up to 140mg taken daily for 14 weeks with several findings indicating the need for close clinical monitor... AS Fleisher,R Raman,ER...
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Gamma-secretase proteolyzes a variety of membrane-associated fragments derived from type I integral membrane proteins, including the amyloid beta-protein precursor, involved in Alzheimer's disease, and the Notch receptor, critical for cellular differentiation. This protease is composed of four integral ...
Upon issuance of this patent, Activesite Biotech will be in a position to exclusively sell, license, and partner the gamma-secretase assays. Activesite Biotech will use the assay to identify and develop novel, effective treatments for Alzheimer's disease (AD). The estimated market value for an...
To evaluate the safety, tolerability, and amyloid beta (Abeta) response to the gamma-secretase inhibitor LY450139 in Alzheimer disease.doi:10.1001/archneur.65.8.1031Fleisher ASRaman RSiemers ERBecerra LClark CMDean RAFarlow ...
heimer's disease]]>doi:US6759404 B2and their pharmaceutical compositions. These novel compounds inhibit the processing of amyloid precursor protein and, more specifically, inhibit the production of Aβ-peptide, thereby acting to prevent the formation of neurological deposits of amyloid protein.Richard ...
Inhibition of gamma-secretase presents a direct target for lowering Aβ production in the brain as a therapy for Alzheimer's disease (AD). However, gamma-secretase is known to process multiple substrates in addition to amyloid precursor protein (APP), most notably Notch, which has limited clinic...
Modulation of the gamma-secretase enzyme, which reduces the production of the amyloidogenic Aβ42 peptide while sparing the production of other Aβ species, is a promising therapeutic approach for the treatment of Alzheimer's disease. Satori has identified a unique class of small molecule gamma-se...
Assay for the diagnosis of alzheimer's disease based on the determination of the ratio of gamma-secretase abeta cleavage products.Described is a method for the diagnosis of Alzheimer's disease (AD) or a particular stage of the disease wh... G Multhaup - EP 被引量: 13发表: 2009年 The...