Gamma-Secretase Inhibitor-Associated Hypophosphatemia in Patients with Desmoid Tumorsdoi:10.1681/ASN.2024acxqb84yWai Lun Will PakMemorial Sloan Kettering Cancer Center, New York, New York, United States;Edgar A. JaimesMemorial Sloan Kettering Cancer Center, New York, New York, United States;Andrea ...
Gamma secretase inhibitors are a first-in-class medications used to treat progressing desmoid tumors that require systemic treatment. Gamma secretase inhibitors work by blocking the activity of gamma secretase, an enzyme that promotes the growth of desmoid tumors. Desmoid tumors, also known as aggressi...
3.2.8 Gamma-secretase inhibitors Interesting evidence indicates that sub-chronic treatment (twice-a-day for 12 days) and acute administration of semagacestat (LY-450139), a gamma-secretase inhibitor, at a dose that reduces Aβ levels produces a reduction in power of hippocampal θ activity elici...
BACKGROUND: Desmoid fibromatosis is a fibroblastic neoplasm driven by aberrations within the WNT pathway, exhibiting mutations in 尾-catenin or APC. We review the long-term follow-up of patients in a phase I study treated with an oral gamma secretase inhibitor, PF-03084014. METHODS: PF-...
New, tolerable {gamma}- secretase inhibitor takes desmoid down a notch. Clin Cancer Res. 2015;21(1):7-9.Hughes DPM, Kummar S, Lazar AJ. New, tolerable g-secretase in- hibitor takes desmoid down a Notch. Clin Cancer Res. 2014;21:7-9....
DESMOID tumorsTHERAPEUTICSThis article discusses a case study of a patient who developed hidradenitis suppurativa (HS)-like inflammatory lesions as a result of treatment with a gamma secretase inhibitor (GSC). HS is a chronic inflammatory disease of the hair follicle, and the development of ...
The gamma secretase activation of the Notch receptor can be targeted with investigational gamma secretase inhibitors. In this case report, we follow the course of 2 patients with desmoid tumors treated with the highly potent, parenterally administered investigational gamma secretase inhibitor AL101, ...