Polypeptide GalNAc-transferase T3 (GalNAc-T3) regulates fibroblast growth factor 23 (FGF23) by-glycosylating Thr178 in a furin proprotein processing motif RHTR鈫揝. FGF23 regulates phosphate homeostasis and deficiency inorresults in hyperphosphatemia and familial tumoral calcinosis. We explored the ...
Besides, patients with lower N stage, lower TNM stage, higher GalNAc-T3 expression got better disease-free survival (DFS), especially the GalNAc-T3Hig/MUC1Low group. The GalNAc-T3Hig/MUC1Low group was an independent predictive factor for DFS. In conclusion, GalNAc-T3 and MUC1 were combined...
T3Inh-1 是一种有效的选择性 ppGalNAc-T3 抑制剂,IC50 为 7 µM。 T3Inh-1 可预防乳腺癌细胞。 T3Inh-1 降低组织细胞和小鼠中的 FGF23 激素水平,而不会引起任何毒副作用。 为众多的药物研发团队赋能, 让新药发现更简单! T3Inh-1 纯度: 97% 产品编号 T9720Cas号 50440-30-7 T3Inh-1 是一种有效...
转移以及分化等有关.GalNAc-Ts(UDP-GalNAc-polypeptide N-acetyl-galactosaminyl transferases)是催化细胞表面蛋白发生粘蛋白型O-糖基化的始动酶,它与恶性肿瘤粘附,侵袭,转移及胞内信号转导密切相关.GalNAc-T3是GalNAc-Ts家族的重要成员.广泛表达于人类正常组织及恶性肿瘤中,国外研究显示:GalNAc-T3与肿瘤的分化,侵袭...
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A novel gene defining a novel enzyme in the UDP-N-acetyl- alpha -D-galactosamine: polypeptide N-acetylgalactosaminyltransferase family, termed GalNAc-T3, with unique enzymatic properties is disclosed. The enzymatic activity of GalNAc-T3 is shown to be distinct from that of two previously identifi...
We have found that one of these enzymes, GalNAc-T3, is overexpressed in human pancreatic cancer tissues, and suppression of GalNAc-T3 significantly attenuates growth of pancreatic cancer cellsin vitroandin vivo. In addition, suppression of GalNAc-T3 induces apoptosis of pancreatic cancer cells. Our...
( 2011 ). Overexpression of GalNAc-transferase GalNAc-T3 promotes pancreatic cancer cell growth . Oncogene 30 : 4843 – 4854 .Taniuchi K, Cerny RL, Tanouchi A, Kohno K, Kotani N, Honke K, et al. Overexpression of GalNAc-transferase GalNAc-T3 pro- motes pancreatic cancer cell growth. ...
GalNAc-T3's structure further reveals the molecular bases for reported disease-causing mutations. Our findings provide an insight into how GalNAc-T isoenzymes achieve isoenzyme-specific nonredundant functions.doi:10.1038/s41589-019-0444-xMatilde de las Rivas...
A novel gene defining a novel enzyme in the UDP-N-acetyl- alpha -D-galactosamine: polypeptide N-acetylgalactosaminyltransferase family, termed GalNAc-T3, with unique enzymatic properties is disclosed. The enzymatic activity of GalNAc-T3 is shown to be distinct from that of two previously ...