Polypeptide GalNAc-transferase T3 (GalNAc-T3) regulates fibroblast growth factor 23 (FGF23) by-glycosylating Thr178 in a furin proprotein processing motif RHTR鈫揝. FGF23 regulates phosphate homeostasis and deficiency inorresults in hyperphosphatemia and familial tumoral calcinosis. We explored the ...
T3Inh-1 是一种有效的选择性 ppGalNAc-T3 抑制剂,IC50 为 7 µM。 T3Inh-1 可预防乳腺癌细胞。 T3Inh-1 降低组织细胞和小鼠中的 FGF23 激素水平,而不会引起任何毒副作用。 规格价格库存数量 1 mg ¥ 932 现货 5 mg ¥ 2,280 现货 10 mg ¥ 3,810 现货 25 mg ¥ 6,120 现货 ...
The UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase, designated GalNAc-T3, exhibits unique functions. Specific acceptor substrates are used by GalNAc-T3 and not by other GalNAc-transferases. The expression pattern of GalNAc-T3 is restricted, and loss of expression is a characteristic feature...
GalNAc-T1 and -T3 showed strict donor substrate specificities for UDP-GalNAc, whereas GalNAc-T2 also utilized UDP-Gal with one peptide acceptor substrate. Glycosylation of peptides based on MUC1 tandem repeat showed that three of five potential sites in the tandem repeat were glycosylated by all...
Keywords: GalNAc-T3; GALNT3; Male fertility; Semen quality; Mucin-type O-linked glycosylation; Spermatozoa 1. Introduction At least in industrialised countries, couples increasingly experience infertility and attend fertility clinics [1]. While male infertility accounts directly for approximately 30% of...
Anti\\u2010GalNAc\\u2010GD1a antibody\\u2013associated Guillain\\u2010Barr\\u00e9 syndrome with a predominantly distal weakness without cranial nerve impai... Hao,Qi,Saida,... - 《Annals of Neurology》 被引量: 0发表: 1999年 Reactivity of natural and induced human antibodies to MUC1 mucin ...
GalNAc-T3's structure further reveals the molecular bases for reported disease-causing mutations. Our findings provide an insight into how GalNAc-T isoenzymes achieve isoenzyme-specific nonredundant functions.doi:10.1038/s41589-019-0444-xMatilde de las Rivas...
A novel gene defining a novel enzyme in the UDP-N-acetyl- alpha -D-galactosamine: polypeptide N-acetylgalactosaminyltransferase family, termed GalNAc-T3, with unique enzymatic properties is disclosed. The enzymatic activity of GalNAc-T3 is shown to be distinct from that of two previously ...
polypeptide N-acetylgalactosaminyl-transferase, GalNAc-T3, pancreatic cancer, O-glycosylation, cell growth, apoptosisO-linked glycans of secreted and membrane bound proteins play an important role in the pathogenesis of pancreatic cancer by modulating immune responses, inflammation, and tumorigenesis. A ...
Mutations in the gene encoding the glycosyltransferase polypeptide GalNAc-T3, which is involved in initiation of O-glycosylation, were recently identified as a cause of the rare autosomal recessive metabolic disorder familial tumoral calcinosis (OMIM 211900). Familial tumoral calcinosis is associated with...