Polypeptide GalNAc-transferase T3 (GalNAc-T3) regulates fibroblast growth factor 23 (FGF23) by-glycosylating Thr178 in a furin proprotein processing motif RHTR鈫揝. FGF23 regulates phosphate homeostasis and deficiency inorresults in hyperphosphatemia and familial tumoral calcinosis. We explored the ...
Ⅰ期肺腺癌GalNAc-T3蛋白表达与淋巴结微转移检测的意义的开题报告背景与研究意义:肺癌是世界范围内最常见的恶性肿瘤之一,据统计,2020年全球有约200万人被诊断为肺癌。早期诊断是治疗肺癌的关键,但由于肺癌的症状不明显,在早期常常被忽略或误诊。为了提高早期诊断的准确率,需要研究可以与肺癌早期诊断相关联的生物标记物。
转移以及分化等有关.GalNAc-Ts(UDP-GalNAc-polypeptide N-acetyl-galactosaminyl transferases)是催化细胞表面蛋白发生粘蛋白型O-糖基化的始动酶,它与恶性肿瘤粘附,侵袭,转移及胞内信号转导密切相关.GalNAc-T3是GalNAc-Ts家族的重要成员.广泛表达于人类正常组织及恶性肿瘤中,国外研究显示:GalNAc-T3与肿瘤的分化,侵袭...
T3Inh-1 是一种有效的选择性 ppGalNAc-T3 抑制剂,IC50 为 7 µM。 T3Inh-1 可预防乳腺癌细胞。 T3Inh-1 降低组织细胞和小鼠中的 FGF23 激素水平,而不会引起任何毒副作用。 规格价格库存数量 1 mg ¥ 932 现货 5 mg ¥ 2,280 现货 10 mg ¥ 3,810 现货 25 mg ¥ 6,120 现货 ...
We have found that one of these enzymes, GalNAc-T3, is overexpressed in human pancreatic cancer tissues, and suppression of GalNAc-T3 significantly attenuates growth of pancreatic cancer cellsin vitroandin vivo. In addition, suppression of GalNAc-T3 induces apoptosis of pancreatic cancer cells. Our...
polypeptide N-acetylgalactosaminyl-transferase, GalNAc-T3, pancreatic cancer, O-glycosylation, cell growth, apoptosisO-linked glycans of secreted and membrane bound proteins play an important role in the pathogenesis of pancreatic cancer by modulating immune responses, inflammation, and tumorigenesis. A ...
A novel gene defining a novel enzyme in the UDP-N-acetyl- alpha -D-galactosamine: polypeptide N-acetylgalactosaminyltransferase family, termed GalNAc-T3, with unique enzymatic properties is disclosed. The enzymatic activity of GalNAc-T3 is shown to be distinct from that of two previously ...
Mutations in the gene encoding the glycosyltransferase polypeptide GalNAc-T3, which is involved in initiation of O-glycosylation, were recently identified as a cause of the rare autosomal recessive metabolic disorder familial tumoral calcinosis (OMIM 211900). Familial tumoral calcinosis is associated with...
The product was deduced to be GalNAcβ1-4GlcNAcβ-benzyl based on mass spectrometry and NMR spectroscopy. We renamed the enzyme β1,4-N-acetylgalactosaminyltransferase-III (β4GalNAc-T3). β4GalNAc-T3 effectively synthesized N,N'-diacetylgalactosediamine, GalNAcβ14GlcNAc, at non-reducing ...