The debate on whether to allow experiments that increase the transmission and/or pathogenicity of potential pandemic pathogens has recently gained renewed attention, particularly as a result of studies on influenza viruses. Here, five experts discuss the
Therefore, after review and approval, we propose to perform experiments that may result in GOF (see'Proposed gain-of-function experiments'). All experiments proposed by influenza investigators are subject to review by institutional biosafety committees. The committees include experts in the fields of ...
Topics include an assessment of the pandemic threat posed by A(H7N9) viruses, the need for gain-of-function (GOF) experiments, and a list of proposed experiments that may result in GOF, including immunogenicity, adaptation, and drug resistance....
Gain-of-Function Experiments on H7N9 Since the end of March 2013, avian a influenza viruses of the H7N9 subtype have caused more than 130 human cases of infection in China, many of which were ... - 《Science》 被引量: 101发表: 2013年 Pandemic influenza viruses: time to recognize our in...
aDozens of tumor suppressors that 许多肿瘤遏抑器那[translate] ahave been discovered through their characteristic inactivation 通过他们的典型钝化作用被发现了[translate] athrough gain- or loss-of-function experiments in mice. 通过获取或损失作用实验在老鼠。[translate]...
Wain-Hobson S: Pandemic influenza viruses: time to recognize our inability to predict the unpredictable and stop dangerous gain-of-function experiments. EMBO Mol Med 2013, 5: 1637–1641. 10.1002/emmm.201303475 CentralWain-Hobson S. Pandemic influenza viruses: time to recognize our inability to ...
求翻译:through gain- or loss-of-function experiments in mice.是什么意思?待解决 悬赏分:1 - 离问题结束还有 through gain- or loss-of-function experiments in mice.问题补充:匿名 2013-05-23 12:21:38 通过对小鼠的收益或损失的功能实验。 匿名 2013-05-23 12:23:18 匿名 2013-05-23 12:...
Infectious Diseases Society of America and Gain-of-Function Experiments With Pathogens Having Pandemic Potential JID Infectious Diseases Society of America and Gain-of- Function Experiments With Pathogens Having Pandemic Potential Gregory M. Frank 7 Amesh Adalja 5 Ala......
In other words, nature is already performing its own gain-of-function experiments, with potentially serious consequences. Pandemic Potential of H7N9 Bird Flu In a few patients with neonatal diabetes, recessive inheritance of two ABCC8 or KCNJ11 gain-of-function mutations or compound heterozygosity for...
Define Gain-of-function. Gain-of-function synonyms, Gain-of-function pronunciation, Gain-of-function translation, English dictionary definition of Gain-of-function. n. 1. The act or process of being altered or changed. 2. An alteration or change, as in n