Notch-regulated periphery B cell differentiation involves suppression of E protein function. J. Immunol. 191, 726–736 (2013). Article CAS PubMed Google Scholar Wakabayashi, N. et al. Regulation of notch1 signaling by nrf2: implications for tissue regeneration. Sci. Signal 3, ra52 (2010)....
Here we report clinical, genetic, and functional investigations in 2 families with early-onset MDS −7/del(7q), identifying heterozygous germ line gain-of-function mutations in SAMD9L and a variable degree of hematological and neurological symptoms. We also uncovered carriers who displayed distinct...
A metal wafer is used as parasitic element, loaded in the front of general axial-mode helical antenna to achieve the aim of improving antenna gain. The diameter of the wafer and the distance between the wafer and the end of the helical wire, which can influence the antenna characteristics, ...
Paolo Cavallerio 4, Valentina Simioni 5, Valeria Tugnoli 5, Francesca Salvatori 1,6* & Peggy Marconi 1,6* SCAs are autosomal dominant neurodegenerative disorders caused by a gain-of-function protein with toxic activities, containing an expanded polyQ tract in the coding...
We show that this gain of function in embryonic development was linked to loss of intronV. Introns, noncoding sequences interrupting protein-coding genes, are the hallmark of eukaryotic gene organization (23). However, the role of intron in AMP gene regulation was previously not known. This ...
doi:10.1111/j.1949-8594.1905.tb04462.xDELIA M. STICKNEYInstructor in Chemistry, English High School, Cambridge, Mass.W.M. L. KIEMANInstructor in Chemistry, English High School, Cambridge, Mass.John Wiley & Sons, LtdSchool ence & Mathematics...
loss-of-function and gain-of-function James Yi-Hsin Chan1,2, Ying-Chuan Chen3, Shu-Ting Liu3, Wei-Yuan Chou3*, Ching-Liang Ho4* and Shih-Ming Huang3* Abstract Background: p53 is a major tumor suppressor that is inactivated in over 50% of human cancer types through either mutation ...
p53 is mutated in over half of human cancers. In addition to losing wild-type (WT) tumor-suppressive function, mutant p53 proteins are proposed to acquire gain-of-function (GOF) activity, leading to novel oncogenic phenotypes. To study mutant p53 GOF mec
cdd Two hot spot mutant p53 mouse models display differential gain of function in tumorigenesis W Hanel1,2, N Marchenko1, S Xu1, S Xiaofeng Yu3,4, W Weng3 and U Moll*,1 Mutant p53 proteins not only lose their tumor-suppressor function but some acquire oncogenic gain of function (GOF)...
Despite this bias, the experiment proved that functional up- regulation of Gαs, per se, preserves most functional as- pects specific of stem cells or of osteoblastic progenitors but it compromises cell organization in the tissue. In summary, by conditioning stem cell maturation, gsp dramatically...