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R.A.M.F. receives research support for gain-of-function research from the US National Institutes of Health (NIH), the US National Institute of Allergy and Infectious Diseases (NIAID) and the European Union. M.L. receives research funding for pneumococcal vaccine modelling projects from PATH ...
S.M.S. received support from the Wellcome Trust (084730), National Institute for Health Research (NIHR) University College London Hospital Biomedical Research Centre and Epilepsy Society, UK. M. Synofzik received support from the Interdisciplinary Center for Clinical Research (IZKF) Tübingen (2191...
We find that a good transfer function "feels like normal walking, but fast" - as one of our participants put it - even for a high-gain value of 10. 1 Some authors have used gain values of up-to 100 (e.g., Williams- Sanders et al. 2019). 2 Related work 2.1 Nonlinear transfer...
The optimized local registration was achieved by using a dilated subcortical mask to constrain the cost function. Regions of interest (ROIs) were extracted from the MNI-defined DBS Intrinsic Template Atlas (DISTAL), which contains 101 thalamic and extra-thalamic nuclei including the STN, the SN, ...
To fit a smooth curve using locfit, the algorithm calculates the predicted value at each point in the domain by using only a fraction of neighboring data points with a kernel function, e.g., tri-cube function. Curves across the whole domain can thus be fitted. Also calculated were the ...
Fig. 2: Functional characterization of SYK variants. a,b, Pedigrees andSYKvariants in patients 1–3.c, A structural model of WT human SYK (PDB ID:4FL2), highlighting the sites of SYK gain-of-function variants (p.Pro342Thr, p.Ala353Thr, p.Met450Ile, p.Ser550Phe and p.Ser550Tyr)...
Ludwig Institute for Cancer Research, University of California at San Diego, La Jolla, CA, USA Qiang Zhu, Jie Jiang, Melissa McAlonis-Downes, Patrick King, Sandrine Da Cruz & Don W. Cleveland Department of Cell Biology, Emory University School of Medicine, Atlanta, GA, USA Jie Jiang Departm...
The guanine-rich RNA sequence binding factor 1 (GRSF1) is an RNA-binding protein of the heterogenous nuclear ribonucleoprotein H/F (hnRNP H/F) family that binds to guanine-rich RNA sequences forming G-quadruplex structures. In mice and humans there are s
Our study contributes to understanding the effects of Syk on macrophage function and the potential mechanisms involved in IBD development. Material and Methods Mice Male SykS544Y and WT C57BL/6 mice were obtained from Professor Dali Li’s research group at East China Normal ...