Through the examination of collected data, a complex association has been observed between the gut microbiota and bone function, involving communication between the host and the microbes. Even though the GM is known to alter bone metabolism, the underlying processes associated with this effect remain...
www.nature.com/npjgenmed ARTICLE OPEN STAT1 gain-of-function heterozygous cell models reveal diverse interferon-signature gene transcriptional responses Ori Scott 1,2,3 ✉, Kyle Lindsay1, Steven Erwood1,4, Antonio Mollica1,5, Chaim M. Roifman2,6, Ronald D. Cohn1,3,4,7 and Evgueni A....
Mutations of ASXL1, encoding a component of the BAP1 histone H2A deubiquitinase complex, occur in human myeloid neoplasms and are uniformly associated with poor prognosis. However, the precise molecular mechanisms through which ASXL1 mutations alter BAP1
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Tags CRISPR-Cas9Gain-of-function MutationsHematopoietic Stem And Progenitor CellsLeukemic TransformationFluorescent ReporterHeterozygous MutationsHomology-directed RepairGene EditingMolecular CloningCodon Optimization
The objective function minimised consists of the weighted differences of fraction enrichments and total abundances of metabolites between the measured and simulated values. The metabolites are lactate, pyruvate and glucose. For metabolite abundances, the error variances were calculated from their respective...
We use essential cookies to make sure the site can function. We also use optional cookies for advertising, personalisation of content, usage analysis, and social media. By accepting optional cookies, you consent to the processing of your personal data - including transfers to third parties. Some...
increase in lactate, alanine, and glucose concentrations in the liver of these animals, but enhanced hepatic cholesterol accumulation without any detrimental effect on liver function. In conclusion, a low dose of CLA corrected the adverse effects associated with MetS without compromising other metabolic...