Gain-of-function 指的是当一个基因或蛋白质发生变异后，导致其功能增强或出现新的功能。这可能包括增加...
生物学与医学研究中，"gain-of-function"（增强型功能）与"loss-of-function"（丧失型功能）是描述基因或蛋白质变异对生物体影响的术语。Gain-of-function变异导致基因或蛋白质功能增强或出现新功能，可能改变蛋白质表达水平、活性或时间、位置表达。此类变异可引发异常现象，如细胞增殖增加、代谢率提升或信...
4)重组冠状病毒增益实验(Gain-of-Function功能获得性)研究资金来自美国及美国政府批准进行重组冠状病毒增益实验。 这一系列由Ralph S. Baric美国研究团队主持的类SARS冠状病毒跨物种感染试验主要是由美国国家...
The debate on whether to allow experiments that increase the transmission and/or pathogenicity of potential pandemic pathogens has recently gained renewed attention, particularly as a result of studies on influenza viruses. Here, five experts discuss the
Box 1: Proposed gain-of-function experiments Immunogenicity.To develop more effective vaccines and determine whether genetic changes that confer altered virulence, host range or transmissibility also change antigenicity. Adaptation.To assist with risk assessment of the pandemic potential of field strains an...
Gain-of-Function Experiments on H7N9 Since the end of March 2013, avian a influenza viruses of the H7N9 subtype have caused more than 130 human cases of infection in China, many of which were ... - 《Science》 被引量: 101发表: 2013年 Pandemic influenza viruses: time to recognize our in...
functiongain增益thyroidmutationshormone TJ19(3)2005 PerspectivesGain-of-functionmutations:atalosstoexplainmolecules-to-manevolutionJeanK.LightnerEvolutionistspointtomutationsasprovidingtherawmaterialnecessaryfortheonward,upwardchangetheybelievehasoccurredsincelifebegan.Mutationswhichaffectanorganismareoftencategorizedintotwo...
Gain-of-function (GOF) research involves experimentation that aims or is expected to (and/or, perhaps, actually does) increase the transmissibility and/or virulence of pathogens. Such research, when conducted by responsible scientists, usually aims to improve understanding of disease causing agents, ...
Gain of Function, GOF单基因致病机理功能获得单基因病的发病机理单基因病的发病机理绝大多数单基因病是由于基因所编码的蛋白质的质和或量的改变所引起。绝大多数单基因病是由于基因所编码的蛋白质的质和或量的改变所引起。失去功能失去
on)绝大多数单基因病是由于基因所编码的蛋白质的质和(或)量的改变所引起。功能获得(Gainoffunction)功能获得( gainoffunetion)是最少见的基因突变改变蛋白质功能的表现形式。对于一个特定的基因功能而言,并非越强越好。如果破坏 了机体的平衡,获得功能也会造成细胞正常生理功能的紊乱,并最终导致疾病的发生。目前已知...