G-protein-signaling modulator 2 (GPSM2) belongs to a protein family that regulates activation of G proteins and plays an important role in mitotic spindle orientation. However, the role of GPSM2 in lung adenocarcinoma (LUAD) is still unclear. In this study, it was found that GPSM2 ...
'GPSM2/G-Protein Signaling Modulator 2/LGN/mPINS (AGS5)' published in 'Encyclopedia of Signaling Molecules'
RUTBC1, CT (SGSM2, KIAA0397, RUTBC1, Small G protein signaling modulator 2, RUN and TBC1 domain-containing protein 1) 供应商 MyBioSource 产品货号 MBS641743 产品报价 ￥询价/0.2mL ￥询价/5x0.2mL ￥询价/其它规格 产品说明书 点击查看 ...
Our previous study showed that ablation of the Gβ5–R7 complex caused a reduction in serum insulin levels in vivo (29), and subsequent experiments with isolated islets and MIN6 cells supported the notion that Gβ5–R7 is a positive modulator of cholinergic stimulation of GSIS (24). Our ...
Nurnberg B., Gudermann T. and Schultz G. (1995) Receptors and G proteins as primary components of transmembrane signal transduction. Part 2. G proteins: structure and function. J. Mol. Med.73: 123–132 ArticlePubMedCASGoogle Scholar
24 Moreover, several GPCRs can be activated by DAMPs 25 , suggesting that RGS proteins (the negative modulator of GPCR signaling pathway) may be potential to regulate pyroptosis in radiotherapy. GSDMD, the key protein that causes pyroptosis, is cleaved by caspase-1 into two parts: the C-term...
Here we show that RGS6 is a key negative modulator of G i/o signaling in SNc DA neurons, with its loss provoking enhance D 2 autoreceptor activity and a subsequent reduction in cAMP-PKA signaling. These data are important as cAMP-PKA signaling has not only been linked to SNc DA neuron...
(JNK) pathway that represents a central stress signaling pathway and critical upstream modulator of the mitochondrial pathway of apoptosis.36 Furthermore, we and others have shown that the phosphatidylinositide 3-kinase (PI3K)/Akt pathway is involved in mediating the protective function of APP.37...
studies suggest that RGS18 is a critical modulator of both megakaryocyte differentiation and hemostatic functions of mature platelets. RGS3, 4, 5, 8, 21—Few Known Functions in the Immune System Little is known about the specific physiological functions of these particular RGS proteins in the ...
BRET G-protein Signaling Modulator G-protein Regulatory Motif Introduction Activators of G-protein signaling (AGS)4 proteins were identified in a functional screen for cDNAs that activated G-protein signaling in the absence of a seven-membrane span receptor (1, 2). The discovery of such regulatory...