Kerlavage, A.R., “G-protein-coupled receptor family”, Current Opinion in Structural Biology, vol. 1, pp. 394-401 (1991).Kerlavage, A.R., " G-protein-coupled receptor family ", Current Opinion in Structural Biology, vol. 1, pp. 394-401 (1991)....
Karasinska JM, George SR, and O'Dowd BF (2003) Family 1 G protein-coupled receptor function in the CNS. Insights from gene knockout mice. Brain Res Brain Res Rev 41:125-152.J.M. Karasinska, S.R. George, B.F. O'Dowd, Family 1 G protein-coupled receptor function in the CNS. ...
Family 1 G protein-coupled receptor function in the CNS: Insights from gene knockout mice. Brain Res. Rev. 41, 125-152. JM Karasinska,SR George,BF O`Dowd - 《Brain Research Reviews》 被引量: 0发表: 2003年 Defects in adaptive energy metabolism with CNS-linked hyperactivity in PGC-1alph...
[名词解释] G蛋白耦联受体(G-proteincoupledreceptor) 相关知识点: 试题来源: 解析 一种与三聚体G蛋白耦联的细胞表面受体。含有7个穿膜区,是迄今发现的最大的受体超家族,其成员有1000多个。与配体结合后通过激活所耦联的G蛋白,启动不同的信号转导通路并导致各种生物学效应。
Atypical expansion in mice of the sensory neuron-specific Mrg G protein-coupled receptor family The Mas-related genes (Mrgs) comprise a family of >50 G protein-coupled receptors (GPCRs), many of which are expressed in specific subsets of nociceptive s... MJ Zylka,X Dong,AL Southwell,......
G protein-coupled receptor (GPCR), the largest class of human membrane proteins, constitutes seven-transmembrane (TM) helices which are structurally preserved in this receptor family. Activation of GPCRs typically involves the translation of extracellular stimulation into intracellular signals through...
其细胞质部分可以与三聚体G蛋白相互作用,其胞浆面第三个环能与鸟苷酸结合蛋白(G蛋白)偶联,通过不同的G蛋白影响腺苷酸环化酶或磷脂酶C,改变细胞内第二信使浓度,以实现跨膜信息传递。此类受体通过G蛋白向下游传递信号,因此又称为G蛋白偶联受体。结果一 题目 G蛋白偶联受体?(G protein coupled receptor) 答案 在...
Structure elucidation of inactive-state GPCRs still mostly relies on X-ray crystallography. The major goal of our work was to create a new GPCR tool that would provide receptor stability and additional soluble surface for crystallization. Towards this ai
G protein-coupled receptors (GPCRs) constitute a large family of receptors that activate intracellular signaling pathways upon detecting specific extracellular ligands. While many aspects of GPCR signaling have been uncovered through decades of studies, some fundamental properties, like its channel capacity...
GPCR(G Protein-Coupled Receptor),即G蛋白偶联受体,是一大类膜蛋白受体的统称。GPCR是人类基因组编码的最大蛋白家族,广泛分布于中枢神经系统、免疫系统、心血管及视网膜等器官和组织,参与机体发育以及多种生理功能的调控。 GPCR的主体由7段跨细胞质膜的α螺旋结构构成,将信号由胞外转导到胞内(图1)。基于进化同源性...