Motif predictionRNA and DNA topologyNucleic acid secondary structureIn vivo discovery of G-quadruplex-forming sequences would provide the most relevant G-quadruplexes along a genomic DNA or an RNA molecule, although is difficult to perform due to the small size of G-quadruplexes, the existence ...
RNA G-quadruplex structure (RG4) prediction Plant transcriptomes were obtained from the resource data of the one thousand plant transcriptomes project6. RNA G-quadruplex features were extracted according to our previous study11, and further assigned to different structural subclasses of G2-RG4 (RG4...
David Tannahill1 & Shankar Balasubramanian1,2,3 The G-quadruplex is an alternative DNA structural motif that is considered to be functionally important in the mammalian genome for transcriptional regulation, DNA replication and genome stability, but the nature and distribution of G-quadruplexes across...
T, C or G; x: the number of nucleotides in the loop. On the basis of the G3+NxG3+NxG3+NxG3+motif, PQS prediction can be performed via several quadparser algorithms, such as pqsfinder [6] and the QGRS Mapper [7].BG-quartet formed by four Gs.CThe G-quadruplex structure formed b...
Structure of a G-quadruplex. Left: a G-tetrad. Right: an intramolecular G-quadruplex 3D Structure of the intramolecular human telomeric G-quadruplex in potassium solution (PDB ID 2HY9). The backbone is represented by a tube. The center of this structure contains three layers of G-tetrads....
G-quadruplex (G4) is a four-stranded helical DNA secondary structure formed by guanine-rich sequence folding, and G4 has been computationally predicted to exist in a wide range of species. Substantial evidence has supported the formation of endogenous G4 (eG4) in living cells and revealed its...
G-quadruplexes (G4s), in general, are guanine-rich repeats in DNA/RNA present in variable (> 2–4) tracts at a certain interval of nucleotides (N). G4s can fold or stack into four-stranded secondary structures [11] and are abundantly present in all domains of life including viruses...
Though RNA G-quadruplexes became a focus of study over a decade ago, the main challenge associated with the identification of new potential G-quadruplexes remains a bottleneck step. It slows the study of these non-canonical structures in nucleic acids, and thus the understanding of their signifi...
Guanine-rich sequences are able to form complex RNA structures termed RNA G-quadruplexes in vitro. Because of their high stability, RNA G-quadruplexes are proposed to exist in vivo and are suggested to be associated with important biological relevance. H
RNA-binding proteins are central for many biological processes and their characterization has demonstrated a broad range of functions as well as a wide spectrum of target structures. RNA G-quadruplexes are important regulatory elements occurring in both