doi:10.1002/jcp.21246Enrique RozengurtJournal of Cellular PhysiologyRozengurt E. Signaling pathways induced by g-protein-coupled recep- tors. In: Physiology of the Gastrointestinal Tract, edited by Johnson LR. New York: Elsevier, 2012, p. 75-96....
Heterotrimeric G-proteins are intracellular partners of G-protein-coupled receptors (GPCRs). GPCRs act on inactive Gα·GDP/Gβγ heterotrimers to promote GDP release and GTP binding, resulting in liberation of Gα from Gβγ. Gα·GTP and Gβγ target effectors including adenylyl cyclases,...
G Protein Signaling Pathways in Health and Disease, Volume 161 in the Progress in Molecular Biology and Translational Science series, provides informative and exciting monographs on a wide variety of research topics related to G Protein Signaling Pathways in Health and Disease. The series gives in-...
信号转导(Signalling transduction):当细胞膜上的受体感受外界信号刺激后,将胞外信号通过跨膜结构转化为胞内信号,并通过胞内信使系统级联放大信号以及蛋白质的可逆磷酸化,调节相应酶或基因的表达,最终引起相应的生理反应,达到维持体内平衡的目的。 G蛋白偶联受体(G-protein-coupled receptor, GPCR):是迄今为止发现的最...
(几个小时甚至几天)两种作用,前者是:GPER控制的非基因组学信号途径(nongenomic signaling pathways)亦即:控制离子通道开/关所形成的快速信号途径;而后者则是由GPER和雌激素受体共同控制的基因组学信号途径(genomic signaling pathways),亦即基因表达和修饰基础上的慢速途径,显然GPER才是这些功能化合物的关键节点,如图1...
(几个小时甚至几天)两种作用,前者是:GPER控制的非基因组学信号途径(nongenomic signaling pathways)亦即:控制离子通道开/关所形成的快速信号途径;而后者则是由GPER和雌激素受体共同控制的基因组学信号途径(genomic signaling pathways),亦即基因表达和修...
The signal transducing G protein is one component of the signaling pathways for the differentiation-inducing molecules such as α-melanocyte-stimulating hormone (α-MSH) and cAMP. To investigate the role of G proteins in the differentiation process, we analyzed the expression of various G proteins ...
Mast cells express multiple regulator of G protein signaling (RGS) proteins G-protein-coupled receptors (GPCRs) contribute to the initiation and propagation of allergic processes. Regulators of G Protein Signaling (RGS) proteins in... BANSAL,G - 《Journal of Allergy & Clinical Immunology》 被引...
G蛋白是一个超级家族(GTP-binding proteins superfamily),包括膜受偶联的异源三聚体G蛋白(Heterotrimeric GTP binding protein).异源三聚体G蛋白,分子量大(100kD左右),是受鸟嘌呤核苷酸调控的超级家族的信号传导分子;而小G蛋白,分子量小(20-30kD),为单体,可能号传导无直接联系。本文仅对与信号传导有关的源三聚体G...
G-protein signalling pathways are involved in sensing the environment, enabling fungi to coordinate cell function, metabolism and development with their surroundings, thereby promoting their survival, propagation and virulence. G-protein-coupled receptor