Synonyms G beta ; G gamma ; G protein beta ; G protein gamma ; Gb ; Gnb ; Gng ; Guanine nucleotide binding protein ; Guanine nucleotide binding protein, beta ; Guanine nucleotide binding protein, beta polypeptide ; Guanine nucleotide binding protein (G protein), gamma ; Guanine nucleotide ...
G protein beta1gamma2 subunits promote microtubule assembly. High affinity interactions of beta gamma with either G protein alpha subunits or effector molecules require that the gamma subunit be prenylated. Furthermore, it appears from this study that prenylation may play a crucial role in mediating...
在静息状态下,G蛋白与受体耦联、其\alpha亚基与\beta\gamma复合体结合,且二磷酸鸟苷与\alpha亚基结合。 当配体与G蛋白耦联受体结合域结合时,\alpha亚基与\beta\gamma复合体解离,同时三磷酸鸟苷替代二磷酸鸟苷与\alpha亚基结合。此时,从\alpha亚基上解离的\beta\gamma复合体与\alpha亚基分别激活受体两侧的两个效应...
Blackmer T., Larsen E.C., Bartleson C., Kowalchyk J.A., Yoon E.J., Preininger A.M., Alford S., Hamm H.E., Martin T.F. 2005. G protein betagamma directly regulates SNARE protein fusion machinery for secretory granule exocytosis . Nat. Neurosci. 8 :421–425...
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[25]Drolet P,Bilodeau L,Chorvatova A,etal.Inhibition of the T-type Ca2+currentby the dopamine D1 receptor in ratadrenal glomerulosa cells:requirement of the combined action of the G betagamma protein subunit and cyclic adenosine 3′,5′-monophosphate[J].Mol Endocrinol,1997,11(4):503-14....
Gs protein (Gsalpha) was not inhibited by nocodazole, indicating that the inhibition of tubulin-Gbetagamma interactions during microtubule depolymerization is selective. We found that Gbetagamma also interacts with gamma-tubulin, colocalizes with gamma-tubulin in centrosomes, and co-sediments in cent...
1999 . G-protein βγ subunit-dependent phosphorylation of 62-kDa protein in the early signaling pathway of starfish oocyte maturation induced by 1-methyladenine . Dev. Biol. 209 , 200 – 209 .Nakano T, Kontani K, Kurosu H, Katada T, Hoshi M, Chiba K. G- protein bg subunit-dependent...
14.touhara,k.,j.inglese,j.a.pitcher,g.shaw和r.j.lefkowitz(1994).″g蛋白βγ亚基与普列克底物蛋白同源域结合(bindingofgproteinbetagamma-subunitstopleckstrinhomologydomains.)″jbiolchem269(14):10217-10220. 15.zhang,j.h.,t.d.chung和k.r.oldenburg(1999).″用于高通量筛选测定的评价和检测的简单...
The guanine nucleotide-binding proteins (G proteins), which transduce hormonal and light signals across the plasma membrane, are heterotrimers composed of alpha, beta, and gamma subunits. Activation of G proteins by guanine nucleotides is accompanied by dissociation of the heterotrimer: G + alpha....