核受体最新综述(包括lxr、rxr、fxr等),fxr 受体,g蛋白偶联受体,受体阻滞剂,阿片受体,雌激素受体,h2受体拮抗剂,toll样受体,b受体阻滞剂,乙酰胆碱受体 文档格式: .pdf 文档大小: 2.52M 文档页数: 69页 顶/踩数: 0/0 收藏人数: 0 评论次数: 0
FXR adopts direct and indirect mechanisms to regulate the transcriptional expression of major carrier proteins of the hepatobiliary transport system. In this context, the relevance of FXR-mediated mechanisms is sustained by a recent work showing that the bile acid (BA)-mediated activation of FXR ...
These changes enhanced the transcriptional activity of FXR by promoting the coactivator binding, thus suggesting a structural basis for the functional permissiveness of the FXR/RXR heterodimer complex. Furthermore, sequence analyses together with functional mutagenesis studies indicated that the helix H10 ...
核受体最新综述(包括LXR、RXR、FXR等)(pdf X页) 文档格式: .pdf 文档大小: 2.52M 文档页数: 69页 顶/踩数: 0/0 收藏人数: 0 评论次数: 0 文档热度: 文档分类: 幼儿/小学教育--教育管理 文档标签: X页 系统标签: fxrlxrrxrmodulatorsreceptor受体 ...
1521-0081/65/2/710 –778$25.00 http://dx.doi.org/10.1124/pr.112.006833P HARMACOLOGICAL R EVIEWS Pharmacol Rev 65:710–778, April 2013Copyright © 2013 by The American Society for Pharmacology and Experimental TherapeuticsASSOCIATE EDITOR: DIANNE M. PEREZNuclear Receptors and Their SelectivePhar...
The Systems Biology of Transporters – Targeting the Regulatory System for Transporters (FXR/RXR)doi:10.1002/9783527679430.ch9bile acid﹎ediated activationfarnesoid X receptorhepatobiliary transport systemhigh‐throughput screening approachesnonsteroidal ligandsregulatory system...
Kassam, AltafMiao, BowmanYoung, Peter RMukherjee, RanjanKassam,A., Miao,B., Young,P.R. & Mukherjee,R. RXR agonist-induced antagonism of FXR activity due to absence of coactivator recruitment and decreased DNA binding. J Biol Chem ., (2003)....
Cai SY, He H, Nguyen T, Mennone A, Boyer JL (2010) Retinoic acid represses CYP7A1 expression in human hepatocytes and HepG2 cells by FXR/RXR- dependent and independent mechanisms. J Lipid Res Epub (ahead of print).CAI S Y,HE H,NGUYEN T,et aal.Retinoic acid represses CYP7A1 ...
Liver genes enriched in FXR/RXR activation pathway IPA analysis of the top 100 probe-sets from theClare, M. LeeManikhandan, A. V. MudaliarD., R. HaggartC., Roland WolfGino, MieleJ., Keith VassDesmond, J. HighamDaniel, Crowther
FXR and nuclear receptor retinoid X receptor 伪 (RXR伪) form a heterodimer that controls the expression of numerous downstream genes. To date, the structural basis and functional consequences of the FXR/RXR heterodimer interaction have remained unclear. Herein, we present the crystal structures of ...