Factor VII deficiencymutation databaseFactor VII (FVII) is a zymogen for a vitamin K-dependent serine protease essential for the initiation of blood coagulation. It is synthesized primarily in the liver and circulates in plasma at a concentration of approximately 0.5 渭g/ml (10 nmol/L). The ...
2. Seifried E, et al. Factor VIIa for prophylaxis and treatment of bleeding in patients without congenital haemophilia. Expert Opin Biol Ther. 2019;19(4):283-289. 3. Hedner U. Recombinant activated factor VII in the treatment of patients with congenital factor VII deficiency. Ther Adv Hemato...
Defining the bleeding risk in patients with FVII-deficiency is not easy. Aim of this study is to define correlation and differences between three different scores and the thrombin generation assay (TGA) in correctly evaluating the hemorrhagic phenotype in a group of FVII-deficient patients. Fifty-...
Review of invasive procedures in patients with FVII and FXIdeficiency in University Hospital Brno between the years2005-2012 来自 Semantic Scholar 喜欢 0 阅读量: 12 作者:G Chlupová,P Smejkal,A. Bulíková,J Kamelander,J Kissová,M. Matková,M. lechtová,M Penka ...
This strategy can also be applied in platelet disorders, FVII deficiency or for prophylaxis in congenital hemophilia complicated by inhibitor development. Methods Plasmid construction, protein purification, and AAV production A pcDNA3-based (Invitrogen, Carlsbad, CA) plasmid vector containing the canine ...
Pharmacokinetic properties of recombinant FVIIa in inherited FVII deficiency account for a large volume of distribution at steady state and a prolonged pha... Pharmacokinetic properties of recombinant FVIIa in inherited FVII deficiency account for a large volume of distribution at steady state and a ...
the recombinat activated factor vii (rfviia novoseven, novonordisk, denmark) has been successfully used in the treatment of hemorrhages in hemophilic patients with inhibitors, in the congenital deficiency of fvii and in glanzmann's thromboasthenia. besides, its use has been recommended in non-hemo...
Acquired hemophilia Afactor VIII deficiencypediatric populationrecombinant factor VII activatedAcquired hemophilia should be evaluated in pediatric patients with bleeding and isolated prolonged aPTT. Immunosuppressive treatment should be initiated even in minor bleedings. Bypassing agents like rFVIIa can be used...
Successful Use of Recombinant Factor VIIa (NovoSeven®) During Cardiac Surgery in a Pediatric Patient with Congenital Factor XI Deficiency Successful use of recombinant factor VIIa (NovoSeven) during cardiac surgery in a pediatric patient with Glanzmann thrombasthenia. Pediatr Cardiol 2005;26:... Z ...
Less common causes of cirrhosis include direct liver injury from inherited disease such as cystic fibrosis, alpha-1-antitrypsin deficiency, hemochromatosis, Wilson's disease, galactosemia, and glycogen storage disease. Transplantation is the key intervention for treating late stage cirrhotic patients....